Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

Dario A. Vitturi; Chen Shan Chen; Steven R. Woodcock; Sonia R. Salvatore; Gustavo Bonacci; Jeffrey R. Koenitzer; Nicolas A. Stewart; Nobunao Wakabayashi; Thomas W. Kensler; Bruce A. Freeman; Francisco J. Schopfer

doi:10.1074/jbc.M113.486282

Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

Dario A. Vitturi, Chen Shan Chen, Steven R. Woodcock, Sonia R. Salvatore, Gustavo Bonacci, Jeffrey R. Koenitzer, Nicolas A. Stewart, Nobunao Wakabayashi, Thomas W. Kensler, Bruce A. Freeman, Francisco J. Schopfer

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

Original language	English (US)
Pages (from-to)	25626-25637
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.486282
State	Published - Aug 30 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.486282

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Vitturi, D. A., Chen, C. S., Woodcock, S. R., Salvatore, S. R., Bonacci, G., Koenitzer, J. R., Stewart, N. A., Wakabayashi, N., Kensler, T. W., Freeman, B. A., & Schopfer, F. J. (2013). Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase. Journal of Biological Chemistry, 288(35), 25626-25637. https://doi.org/10.1074/jbc.M113.486282

Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase. / Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo; Koenitzer, Jeffrey R.; Stewart, Nicolas A.; Wakabayashi, Nobunao; Kensler, Thomas W.; Freeman, Bruce A.; Schopfer, Francisco J.

In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25626-25637.

Research output: Contribution to journal › Article › peer-review

Vitturi, Dario A. ; Chen, Chen Shan ; Woodcock, Steven R. ; Salvatore, Sonia R. ; Bonacci, Gustavo ; Koenitzer, Jeffrey R. ; Stewart, Nicolas A. ; Wakabayashi, Nobunao ; Kensler, Thomas W. ; Freeman, Bruce A. ; Schopfer, Francisco J. / Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 35. pp. 25626-25637.

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title = "Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase",

abstract = "Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.",

author = "Vitturi, {Dario A.} and Chen, {Chen Shan} and Woodcock, {Steven R.} and Salvatore, {Sonia R.} and Gustavo Bonacci and Koenitzer, {Jeffrey R.} and Stewart, {Nicolas A.} and Nobunao Wakabayashi and Kensler, {Thomas W.} and Freeman, {Bruce A.} and Schopfer, {Francisco J.}",

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AU - Vitturi, Dario A.

AU - Chen, Chen Shan

AU - Woodcock, Steven R.

AU - Salvatore, Sonia R.

AU - Bonacci, Gustavo

AU - Koenitzer, Jeffrey R.

AU - Stewart, Nicolas A.

AU - Wakabayashi, Nobunao

AU - Kensler, Thomas W.

AU - Freeman, Bruce A.

AU - Schopfer, Francisco J.

PY - 2013/8/30

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N2 - Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

AB - Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

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Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

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