Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

Dario A. Vitturi, Chen Shan Chen, Steven R. Woodcock, Sonia R. Salvatore, Gustavo Bonacci, Jeffrey R. Koenitzer, Nicolas A. Stewart, Nobunao Wakabayashi, Thomas W. Kensler, Bruce A. Freeman, Francisco J. Schopfer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

Original languageEnglish (US)
Pages (from-to)25626-25637
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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