Vasoactivity represents a major concern for the in vivo use of cell free hemoglobin believed to result from the interaction of hemoglobin with the endothelium-derived relaxing factor (EDRF). Strong evidence shows that EDRF is in fact nitric oxide (NO). The high affinity of NO for hemoglobin is due to its extremely low dissociation reaction. An increase in NO dissociation will result in a decreased affinity for NO. These indicate that the affinity for NO can be affected by amino acid substitutions in the heme pocket.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1 1994|
|Event||Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA|
Duration: Jul 24 1994 → Jul 27 1994
ASJC Scopus subject areas
- Biomedical Engineering