Modulation of myocardial contraction by peroxynitrite

Mark Kohr, Steve R. Roof, Jay L. Zweier, Mark T. Ziolo

Research output: Contribution to journalArticle

Abstract

Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca2+ handling, proposed signaling pathways, and protein end-targets. The heart plays a vital role in the cardiovascular system by providing the specialized tissues and organs of the body with a continual supply of oxygen and other essential nutrients. Modulation of myocardial contraction allows the heart to meet the demands of the body despite continual changes in metabolism. This modulation occurs at several different levels, including the level of the ventricular cardiomyocyte.

Original languageEnglish (US)
Article numberArticle 468
JournalFrontiers in Physiology
Volume3 DEC
DOIs
StatePublished - 2012

Fingerprint

Myocardial Contraction
Peroxynitrous Acid
Cardiac Myocytes
Cardiovascular System
Oxidants
Oxygen
Food
Health
Proteins

Keywords

  • Ca
  • cAMP-dependent protein kinase
  • Myocyte
  • Nitric oxide synthase
  • Peroxynitrite
  • protein phosphatase 2a

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Modulation of myocardial contraction by peroxynitrite. / Kohr, Mark; Roof, Steve R.; Zweier, Jay L.; Ziolo, Mark T.

In: Frontiers in Physiology, Vol. 3 DEC, Article 468, 2012.

Research output: Contribution to journalArticle

Kohr, Mark ; Roof, Steve R. ; Zweier, Jay L. ; Ziolo, Mark T. / Modulation of myocardial contraction by peroxynitrite. In: Frontiers in Physiology. 2012 ; Vol. 3 DEC.
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