Modulation of myocardial contraction by peroxynitrite

Mark J. Kohr, Steve R. Roof, Jay L. Zweier, Mark T. Ziolo

Research output: Contribution to journalReview articlepeer-review


Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca2+ handling, proposed signaling pathways, and protein end-targets. The heart plays a vital role in the cardiovascular system by providing the specialized tissues and organs of the body with a continual supply of oxygen and other essential nutrients. Modulation of myocardial contraction allows the heart to meet the demands of the body despite continual changes in metabolism. This modulation occurs at several different levels, including the level of the ventricular cardiomyocyte.

Original languageEnglish (US)
Article numberArticle 468
JournalFrontiers in Physiology
Volume3 DEC
StatePublished - 2012


  • Ca
  • Myocyte
  • Nitric oxide synthase
  • Peroxynitrite
  • cAMP-dependent protein kinase
  • protein phosphatase 2a

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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