Modulation of Kv4.3 current by accessory subunits

Isabelle Deschênes, Gordon F. Tomaselli

Research output: Contribution to journalArticle

Abstract

Kv4.3 encodes the pore-forming subunit of the cardiac transient outward potassium current (Ito). hKv4.3-encoded current does not fully replicate cardiac Ito, suggesting a functionally significant role for accessory subunits. KChIP2 associates with Kv4.3 and modifies hKv4.3-encoded currents but does not replicate native Ito. We examined the effect of several ancillary subunits expressed in the heart on hKv4.3-encoded currents. Remarkably, the ancillary subunits Kvβ3, minK, MiRP-1, the Na channel β1 and KChIP2 increased the density and modified the gating of hKv4.3 current. hKv4.3 promiscuously assembles with ancillary subunits in vitro, functionally modifying the encoded currents; however, the physiological significance is uncertain.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalFEBS Letters
Volume528
Issue number1-3
DOIs
StatePublished - Sep 25 2002

Keywords

  • Accessory subunit
  • Ion channel
  • Potassium

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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