Modulation of kinin responses in human synovium by interleukin-1

J. M. Bathon, J. E. Croghan, D. W. Goldman, D. W. MacGlashan, D. Proud

Research output: Contribution to journalArticlepeer-review

Abstract

Bradykinin (BK) is a weak stimulus for prostaglandin E2 (PGE2) release in untreated human synovial cells, but a potent stimulus in interleukin-1 (IL-1) pretreated cells. The mechanism(s) by which IL-1 induces responsiveness of synovial cells to BK appears to be multifactorial. IL-1 not only upregulates the number of kinin receptors on these cells, but may also upregulate a calcium-dependent process involved in the synthesis of prostaglandins.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalAgents and Actions
Volume38
Issue numberSUPPL. II
StatePublished - 1992

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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