@article{9da3ad85933b42b0a5cab3be2b5e37ff,
title = "Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy",
abstract = "Sublingual (SLIT) and oral immunotherapy (OIT) are promising treatments for food allergy, but underlying mechanisms are poorly understood. Dendritic cells (DCs) induce and maintain Th2-type allergen-specific T cells, and also regulate innate immunity through their expression of Toll-like receptors (TLRs). We examined how SLIT and OIT influenced DC innate and adaptive immune responses in children with IgE-mediated cow's milk (CM) allergy. SLIT, but not OIT, decreased TLR-induced IL-6 secretion by myeloid DCs (mDCs). SLIT and OIT altered mDC IL-10 secretion, a potent inhibitor of FcεRI-dependent pro-inflammatory responses. OIT uniquely augmented IFN-α and decreased IL-6 secretion by plasmacytoid DCs (pDCs), which was associated with reduced TLR-induced IL-13 release in pDC-T cell co-cultures. Both SLIT and OIT decreased Th2 cytokine secretion to CM in pDC-T, but not mDC-T, co-cultures. Therefore, SLIT and OIT exert unique effects on DC-driven innate and adaptive immune responses, which may inhibit allergic inflammation and promote tolerance.",
keywords = "Adaptive immunity, Dendritic cell, Food allergy, Immunotherapy, Innate immunity, Tolerance",
author = "Frischmeyer-Guerrerio, {Pamela A.} and Keet, {Corinne A.} and Guerrerio, {Anthony L.} and Chichester, {Kristin L.} and Bieneman, {Anja P.} and Hamilton, {Robert G.} and Wood, {Robert A.} and Schroeder, {John T.}",
note = "Funding Information: P.A. Frischmeyer-Guerrerio, J.T. Schroeder, A.L. Guerrerio and C.A. Keet have received research support from NIH. R.A. Wood has consulted for the Asthma and Allergy Foundation of America; has received research support from NIH; and is on the medical advisory board for the Food Allergy and Anaphylaxis Network. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: This work was supported by NIH grant K23AI091869 (to P.A.F.-G.), a Johns Hopkins Clinician Scientist Award (to P.A.F.-G.), an ARTrust Faculty Development Grant (to P.A.F.-G.), NIH grant R21AI079853 (to J.T.S.), and the Eudowood Foundation . Assistance with statistics was provided by Carol B. Thompson, Assistant Scientist, Johns Hopkins Biostatistics Center, who was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health through Grant Number 101872 .",
year = "2014",
month = aug,
day = "19",
doi = "10.1016/j.clim.2014.08.006",
language = "English (US)",
volume = "155",
pages = "47--59",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "1",
}