Abstract
The rising incidence of obesity, as a disorder of energy metabolism, has provoked a search for pharmacological agents that either increase energy expenditure or reduce food intake. The fatty acid oxidation pathway, and its rate-limiting enzyme carnitine palmitoyltransferase (CPT)-1 are potential targets for the treatment of obesity. The modulation of CPT-1 may simultaneously affect energy metabolism and food intake to aid in the management of obesity. Both the inhibition and enhancement of CPT-1 activity are currently under investigation as strategies for the treatment of obesity. In this review, key data on both sides of the 'CPT-1 activity balance' as they relate to obesity therapy are discussed.
Original language | English (US) |
---|---|
Pages (from-to) | 312-317 |
Number of pages | 6 |
Journal | Current Opinion in Investigational Drugs |
Volume | 8 |
Issue number | 4 |
State | Published - Apr 2007 |
Keywords
- Carnitine palmitoyltransferase-1
- CPT-1 inhibition
- CPT-1 stimulation
- Fatty acid oxidation
- Feeding behavior
- Malonyl-CoA
- Obesity
ASJC Scopus subject areas
- Pharmacology