Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity

Francis P. Kuhajda, Gabriele V. Ronnett

Research output: Contribution to journalArticlepeer-review

Abstract

The rising incidence of obesity, as a disorder of energy metabolism, has provoked a search for pharmacological agents that either increase energy expenditure or reduce food intake. The fatty acid oxidation pathway, and its rate-limiting enzyme carnitine palmitoyltransferase (CPT)-1 are potential targets for the treatment of obesity. The modulation of CPT-1 may simultaneously affect energy metabolism and food intake to aid in the management of obesity. Both the inhibition and enhancement of CPT-1 activity are currently under investigation as strategies for the treatment of obesity. In this review, key data on both sides of the 'CPT-1 activity balance' as they relate to obesity therapy are discussed.

Original languageEnglish (US)
Pages (from-to)312-317
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Volume8
Issue number4
StatePublished - Apr 2007

Keywords

  • Carnitine palmitoyltransferase-1
  • CPT-1 inhibition
  • CPT-1 stimulation
  • Fatty acid oxidation
  • Feeding behavior
  • Malonyl-CoA
  • Obesity

ASJC Scopus subject areas

  • Pharmacology

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