Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine

Sujata Ohri; Dipali Sharma; Aparna Dixit

doi:10.1006/cbir.2001.0825

Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine

Sujata Ohri, Dipali Sharma, Aparna Dixit

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Expression of the two proto-oncogenes, c-myc and c-fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated. A significant increase in the expression of both c-myc and c-fos was observed, attaining a peak at 30 min, followed by a gradual decline for 8 h after partial hepatectomy. Treatment of partially hepatectomized animals with MPG resulted in a significant decrease in the expression of both genes, the decrease being more marked in c-myc mRNA levels. At later time points, there was a very small rise in the mRNA levels of these genes in MPG-treated animals but they still remained much lower than the peak levels observed in both genes 30 min after surgery. A decline in the recovery of liver weight in MPG-treated animals was also observed.

Original language	English (US)
Pages (from-to)	187-192
Number of pages	6
Journal	Cell biology international
Volume	26
Issue number	2
DOIs	https://doi.org/10.1006/cbir.2001.0825
State	Published - 2002
Externally published	Yes

Keywords

MPG
Regenerating liver
c-fos
c-myc

ASJC Scopus subject areas

Cell Biology

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10.1006/cbir.2001.0825

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title = "Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine",

abstract = "Expression of the two proto-oncogenes, c-myc and c-fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated. A significant increase in the expression of both c-myc and c-fos was observed, attaining a peak at 30 min, followed by a gradual decline for 8 h after partial hepatectomy. Treatment of partially hepatectomized animals with MPG resulted in a significant decrease in the expression of both genes, the decrease being more marked in c-myc mRNA levels. At later time points, there was a very small rise in the mRNA levels of these genes in MPG-treated animals but they still remained much lower than the peak levels observed in both genes 30 min after surgery. A decline in the recovery of liver weight in MPG-treated animals was also observed.",

keywords = "MPG, Regenerating liver, c-fos, c-myc",

author = "Sujata Ohri and Dipali Sharma and Aparna Dixit",

note = "Funding Information: This work has been supported by a research grant (#37(834)/94-EMR-II) from the Council of Scientific and Industrial Research (CSIR), India, to A.D. CSIR is also acknowledged for the JRF and SRF awards to S.O. and D.S. Mr Samaresh Singh is acknowledged for providing excellent technical assistance.",

year = "2002",

doi = "10.1006/cbir.2001.0825",

language = "English (US)",

volume = "26",

pages = "187--192",

journal = "Cell Biology International Reports",

issn = "1065-6995",

publisher = "Portland Press Ltd.",

number = "2",

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T1 - Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine

AU - Ohri, Sujata

AU - Sharma, Dipali

AU - Dixit, Aparna

N1 - Funding Information: This work has been supported by a research grant (#37(834)/94-EMR-II) from the Council of Scientific and Industrial Research (CSIR), India, to A.D. CSIR is also acknowledged for the JRF and SRF awards to S.O. and D.S. Mr Samaresh Singh is acknowledged for providing excellent technical assistance.

PY - 2002

Y1 - 2002

N2 - Expression of the two proto-oncogenes, c-myc and c-fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated. A significant increase in the expression of both c-myc and c-fos was observed, attaining a peak at 30 min, followed by a gradual decline for 8 h after partial hepatectomy. Treatment of partially hepatectomized animals with MPG resulted in a significant decrease in the expression of both genes, the decrease being more marked in c-myc mRNA levels. At later time points, there was a very small rise in the mRNA levels of these genes in MPG-treated animals but they still remained much lower than the peak levels observed in both genes 30 min after surgery. A decline in the recovery of liver weight in MPG-treated animals was also observed.

AB - Expression of the two proto-oncogenes, c-myc and c-fos, in proliferating liver, and the modulation of their expression by 2-mercaptopropionylglycine (MPG) has been investigated. A significant increase in the expression of both c-myc and c-fos was observed, attaining a peak at 30 min, followed by a gradual decline for 8 h after partial hepatectomy. Treatment of partially hepatectomized animals with MPG resulted in a significant decrease in the expression of both genes, the decrease being more marked in c-myc mRNA levels. At later time points, there was a very small rise in the mRNA levels of these genes in MPG-treated animals but they still remained much lower than the peak levels observed in both genes 30 min after surgery. A decline in the recovery of liver weight in MPG-treated animals was also observed.

KW - MPG

KW - Regenerating liver

KW - c-fos

KW - c-myc

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SN - 1065-6995

VL - 26

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JO - Cell Biology International Reports

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ER -

Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine

Abstract

Keywords

ASJC Scopus subject areas

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