Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.

R. Sircar, H. Samaan, R. Nichtenhauser, L. D. Snell, K. M. Johnson, J. Rivier, W. Vale, R. S. Zukin, S. R. Zukin

Research output: Contribution to journalArticle

Abstract

Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalNIDA research monograph
Volume75
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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    Sircar, R., Samaan, H., Nichtenhauser, R., Snell, L. D., Johnson, K. M., Rivier, J., Vale, W., Zukin, R. S., & Zukin, S. R. (1986). Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands. NIDA research monograph, 75, 157-160.