Modulating T-cell homeostasis with IL-7: Preclinical and clinical studies

C. M. Capitini, A. A. Chisti, C. L. MacKall

Research output: Contribution to journalReview article

Abstract

Capitini CM, Chisti AA, Mackall CL (National Cancer Institute, National Institutes of Health, Bethesda, MD; USA). Modulating T-cell homeostasis with IL-7: preclinical and clinical studies (Review).J Intern Med 2009; 266: 141-153. Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.

Original languageEnglish (US)
Pages (from-to)141-153
Number of pages13
JournalJournal of Internal Medicine
Volume266
Issue number2
DOIs
StatePublished - Aug 1 2009

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Keywords

  • Cytokines
  • Immunotherapy
  • Lymphopenia
  • T cell

ASJC Scopus subject areas

  • Internal Medicine

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