Modular 'click-in-emulsion' bone-targeted nanogels

Daniel A. Heller, Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, Gaurav Sahay, Avi Schroeder, Josh E. Schroeder, Yieu Chyan, Christopher Zurenko, William Querbes, Miguel Manzano, Daniel S. Kohane, Robert Langer, Daniel G. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.

Original languageEnglish (US)
Pages (from-to)1449-1454
Number of pages6
JournalAdvanced Materials
Volume25
Issue number10
DOIs
StatePublished - Mar 13 2013

Keywords

  • bones
  • drug delivery
  • nanogels
  • nanotechnology
  • polymers

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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