Modular 'click-in-emulsion' bone-targeted nanogels

Daniel A. Heller; Yair Levi; Jeisa M. Pelet; Joshua C. Doloff; Jasmine Wallas; George W. Pratt; Shan Jiang; Gaurav Sahay; Avi Schroeder; Josh E. Schroeder; Yieu Chyan; Christopher Zurenko; William Querbes; Miguel Manzano; Daniel S. Kohane; Robert Langer; Daniel G. Anderson

doi:10.1002/adma.201202881

Modular 'click-in-emulsion' bone-targeted nanogels

Daniel A. Heller, Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, Gaurav Sahay, Avi Schroeder, Josh E. Schroeder, Yieu Chyan, Christopher Zurenko, William Querbes, Miguel Manzano, Daniel S. Kohane, Robert Langer, Daniel G. Anderson

School of Medicine

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.

Original language	English (US)
Pages (from-to)	1449-1454
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	10
DOIs	https://doi.org/10.1002/adma.201202881
State	Published - Mar 13 2013

Keywords

bones
drug delivery
nanogels
nanotechnology
polymers

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201202881

Cite this

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title = "Modular 'click-in-emulsion' bone-targeted nanogels",

abstract = "A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.",

keywords = "bones, drug delivery, nanogels, nanotechnology, polymers",

author = "Heller, {Daniel A.} and Yair Levi and Pelet, {Jeisa M.} and Doloff, {Joshua C.} and Jasmine Wallas and Pratt, {George W.} and Shan Jiang and Gaurav Sahay and Avi Schroeder and Schroeder, {Josh E.} and Yieu Chyan and Christopher Zurenko and William Querbes and Miguel Manzano and Kohane, {Daniel S.} and Robert Langer and Anderson, {Daniel G.}",

year = "2013",

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doi = "10.1002/adma.201202881",

language = "English (US)",

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journal = "Advanced Materials",

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T1 - Modular 'click-in-emulsion' bone-targeted nanogels

AU - Heller, Daniel A.

AU - Levi, Yair

AU - Pelet, Jeisa M.

AU - Doloff, Joshua C.

AU - Wallas, Jasmine

AU - Pratt, George W.

AU - Jiang, Shan

AU - Sahay, Gaurav

AU - Schroeder, Avi

AU - Schroeder, Josh E.

AU - Chyan, Yieu

AU - Zurenko, Christopher

AU - Querbes, William

AU - Manzano, Miguel

AU - Kohane, Daniel S.

AU - Langer, Robert

AU - Anderson, Daniel G.

PY - 2013/3/13

Y1 - 2013/3/13

N2 - A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.

AB - A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.

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KW - drug delivery

KW - nanogels

KW - nanotechnology

KW - polymers

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Modular 'click-in-emulsion' bone-targeted nanogels

Abstract

Keywords

ASJC Scopus subject areas

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