TY - JOUR
T1 - MODULAR ANALYTICS
T2 - A new approach to automation in the clinical laboratory
AU - Horowitz, Gary L.
AU - Zaman, Zahur
AU - Blanckaert, Norbert J.C.
AU - Chan, Daniel W.
AU - DuBois, Jeffrey A.
AU - Golaz, Olivier
AU - Mensi, Noury
AU - Keller, Franz
AU - Stolz, Herbert
AU - Klingler, Karl
AU - Marocchi, Alessandro
AU - Prencipe, Lorenzo
AU - McLawhon, Ronald W.
AU - Nilsen, Olaug L.
AU - Oellerich, Michael
AU - Luthe, Hilmar
AU - Orsonneau, Jean Luc
AU - Richeux, Gérard
AU - Recio, Fernando
AU - Roldan, Esther
AU - Rymo, Lars
AU - Wicktorsson, Anne Charlotte
AU - Welch, Shirley L.
AU - Wieland, Heinrich
AU - Grawitz, Andrea Busse
AU - Mitsumaki, Hiroshi
AU - McGovern, Margaret
AU - Ng, Katherine
AU - Stockmann, Wolfgang
PY - 2005/1
Y1 - 2005/1
N2 - MODULAR ANALYTICS (Roche Diagnostics) (MODULAR ANALYTICS, Elecsys and Cobas Integra are trademarks of a member of the Roche Group) represents a new approach to automation for the clinical chemistry laboratory. It consists of a control unit, a core unit with a bidirectional multitrack rack transportation system, and three distinct kinds of analytical modules: an ISE-module, a P800 module (44 photometric tests, throughput of up to 800 tests/h), and a D2400 module (16 photometric tests, throughput up to 2400 tests/h). MODULAR ANALYTICS allows customised configurations for various laboratory workloads. The performance and practicability of MODULAR ANALYTICS were evaluated in an international multicentre study at 16 sites. Studies included precision, accuracy, analytical range, carry-over, and workflow assessment. More than 700 000 results were obtained during the course of the study. Median between-day CVs were typically less than 3% for clinical chemistries and less than 6% for homogeneous immunoassays. Median recoveries for nearly all standardised reference materials were within 5% of assigned values. Method comparisons versus current existing routine instrumentation were clinically acceptable in all cases. During the workflow studies, the work from three to four single workstations was transferred to MODULAR ANALYTICS, which offered over 100 possible methods, with reduction in sample splitting, handling errors, and turnaround time. Typical sample processing time on MODULAR ANALYTICS was less than 30 minutes, an improvement from the current laboratory systems. By combining multiple analytic units in flexible ways, MODULAR ANALYTICS met diverse laboratory needs and offered improvement in workflow over current laboratory situations. It increased overall efficiency while maintaining (or improving) quality.
AB - MODULAR ANALYTICS (Roche Diagnostics) (MODULAR ANALYTICS, Elecsys and Cobas Integra are trademarks of a member of the Roche Group) represents a new approach to automation for the clinical chemistry laboratory. It consists of a control unit, a core unit with a bidirectional multitrack rack transportation system, and three distinct kinds of analytical modules: an ISE-module, a P800 module (44 photometric tests, throughput of up to 800 tests/h), and a D2400 module (16 photometric tests, throughput up to 2400 tests/h). MODULAR ANALYTICS allows customised configurations for various laboratory workloads. The performance and practicability of MODULAR ANALYTICS were evaluated in an international multicentre study at 16 sites. Studies included precision, accuracy, analytical range, carry-over, and workflow assessment. More than 700 000 results were obtained during the course of the study. Median between-day CVs were typically less than 3% for clinical chemistries and less than 6% for homogeneous immunoassays. Median recoveries for nearly all standardised reference materials were within 5% of assigned values. Method comparisons versus current existing routine instrumentation were clinically acceptable in all cases. During the workflow studies, the work from three to four single workstations was transferred to MODULAR ANALYTICS, which offered over 100 possible methods, with reduction in sample splitting, handling errors, and turnaround time. Typical sample processing time on MODULAR ANALYTICS was less than 30 minutes, an improvement from the current laboratory systems. By combining multiple analytic units in flexible ways, MODULAR ANALYTICS met diverse laboratory needs and offered improvement in workflow over current laboratory situations. It increased overall efficiency while maintaining (or improving) quality.
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UR - http://www.scopus.com/inward/citedby.url?scp=27644588080&partnerID=8YFLogxK
U2 - 10.1155/JAMMC.2005.8
DO - 10.1155/JAMMC.2005.8
M3 - Article
C2 - 18924721
AN - SCOPUS:27644588080
SN - 1463-9246
VL - 2005
SP - 8
EP - 25
JO - Journal of Automated Methods and Management in Chemistry
JF - Journal of Automated Methods and Management in Chemistry
IS - 1
ER -