MODULAR ANALYTICS: A new approach to automation in the clinical laboratory

Gary L. Horowitz, Zahur Zaman, Norbert J.C. Blanckaert, Daniel W. Chan, Jeffrey A. DuBois, Olivier Golaz, Noury Mensi, Franz Keller, Herbert Stolz, Karl Klingler, Alessandro Marocchi, Lorenzo Prencipe, Ronald W. McLawhon, Olaug L. Nilsen, Michael Oellerich, Hilmar Luthe, Jean Luc Orsonneau, Gérard Richeux, Fernando Recio, Esther RoldanLars Rymo, Anne Charlotte Wicktorsson, Shirley L. Welch, Heinrich Wieland, Andrea Busse Grawitz, Hiroshi Mitsumaki, Margaret McGovern, Katherine Ng, Wolfgang Stockmann

Research output: Contribution to journalArticlepeer-review

Abstract

MODULAR ANALYTICS (Roche Diagnostics) (MODULAR ANALYTICS, Elecsys and Cobas Integra are trademarks of a member of the Roche Group) represents a new approach to automation for the clinical chemistry laboratory. It consists of a control unit, a core unit with a bidirectional multitrack rack transportation system, and three distinct kinds of analytical modules: an ISE-module, a P800 module (44 photometric tests, throughput of up to 800 tests/h), and a D2400 module (16 photometric tests, throughput up to 2400 tests/h). MODULAR ANALYTICS allows customised configurations for various laboratory workloads. The performance and practicability of MODULAR ANALYTICS were evaluated in an international multicentre study at 16 sites. Studies included precision, accuracy, analytical range, carry-over, and workflow assessment. More than 700 000 results were obtained during the course of the study. Median between-day CVs were typically less than 3% for clinical chemistries and less than 6% for homogeneous immunoassays. Median recoveries for nearly all standardised reference materials were within 5% of assigned values. Method comparisons versus current existing routine instrumentation were clinically acceptable in all cases. During the workflow studies, the work from three to four single workstations was transferred to MODULAR ANALYTICS, which offered over 100 possible methods, with reduction in sample splitting, handling errors, and turnaround time. Typical sample processing time on MODULAR ANALYTICS was less than 30 minutes, an improvement from the current laboratory systems. By combining multiple analytic units in flexible ways, MODULAR ANALYTICS met diverse laboratory needs and offered improvement in workflow over current laboratory situations. It increased overall efficiency while maintaining (or improving) quality.

Original languageEnglish (US)
Pages (from-to)8-25
Number of pages18
JournalJournal of Automated Methods and Management in Chemistry
Volume2005
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering (miscellaneous)
  • Instrumentation
  • Computer Science Applications

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