Modifying the Medical Research Council grading system through Rasch analyses

Els Karla Vanhoutte, Catharina Gerritdina Faber, Sonja Ingrid Van Nes, Bart Casper Jacobs, Pieter Antoon Van Doorn, Rinske Van Koningsveld, David Cornblath, Anneke Jelly Van Der Kooi, Elisabeth Aviva Cats, Leonard Hendrik Van Den Berg, Nicolette Claudia Notermans, Willem Lodewijk Van Der Pol, Mieke Catharina Elisabeth Hermans, Nadine Anna Maria Elisabeth Van Der Beek, Kenneth Craig Gorson, Marijke Eurelings, Jeroen Engelsman, Hendrik Boot, Ronaldus Jacobus Meijer, Giuseppe LauriaAlan Tennant, Ingemar Sergio José Merkies

Research output: Contribution to journalArticle

Abstract

The Medical Research Council grading system has served through decades for the evaluation of muscle strength and has been recognized as a cardinal feature of daily neurological, rehabilitation and general medicine examination of patients, despite being respectfully criticized due to the unequal width of its response options. No study has systematically examined, through modern psychometric approach, whether physicians are able to properly use the Medical Research Council grades. The objectives of this study were: (i) to investigate physicians' ability to discriminate among the Medical Research Council categories in patients with different neuromuscular disorders and with various degrees of weakness through thresholds examination using Rasch analysis as a modern psychometric method; (ii) to examine possible factors influencing physicians' ability to apply the Medical Research Council categories through differential item function analyses; and (iii) to examine whether the widely used Medical Research Council 12 muscles sum score in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy would meet Rasch model's expectations. A total of 1065 patients were included from nine cohorts with the following diseases: Guillain-Barré syndrome (n=480); myotonic dystrophy type-1 (n=169); chronic inflammatory demyelinating polyradiculoneuropathy (n=139); limb-girdle muscular dystrophy (n=105); multifocal motor neuropathy (n=102); Pompe's disease (n=62) and monoclonal gammopathy of undetermined related polyneuropathy (n=8). Medical Research Council data of 72 muscles were collected. Rasch analyses were performed on Medical Research Council data for each cohort separately and after pooling data at the muscle level to increase category frequencies, and on the Medical Research Council sum score in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. Disordered thresholds were demonstrated in 74-79 of the muscles examined, indicating physicians' inability to discriminate between most Medical Research Council categories. Factors such as physicians' experience or illness type did not influence these findings. Thresholds were restored after rescoring the Medical Research Council grades from six to four options (0, paralysis; 1, severe weakness; 2, slight weakness; 3, normal strength). The Medical Research Council sum score acceptably fulfilled Rasch model expectations after rescoring the response options and creating subsets to resolve local dependency and item bias on diagnosis. In conclusion, a modified, Rasch-built four response category Medical Research Council grading system is proposed, resolving clinicians' inability to differentiate among its original response categories and improving clinical applicability. A modified Medical Research Council sum score at the interval level is presented and is recommended for future studies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.

Original languageEnglish (US)
Pages (from-to)1639-1649
Number of pages11
JournalBrain
Volume135
Issue number5
DOIs
StatePublished - 2012

Fingerprint

Biomedical Research
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Physicians
Muscles
Aptitude
Psychometrics
Limb-Girdle Muscular Dystrophies
Glycogen Storage Disease Type II
Myotonic Dystrophy
Paraproteinemias
Polyneuropathies
Muscle Strength
Paralysis
Meta-Analysis
Medicine

Keywords

  • manual muscle testing
  • MRC
  • neuromuscular disorders
  • Rasch

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Vanhoutte, E. K., Faber, C. G., Van Nes, S. I., Jacobs, B. C., Van Doorn, P. A., Van Koningsveld, R., ... Merkies, I. S. J. (2012). Modifying the Medical Research Council grading system through Rasch analyses. Brain, 135(5), 1639-1649. https://doi.org/10.1093/brain/awr318

Modifying the Medical Research Council grading system through Rasch analyses. / Vanhoutte, Els Karla; Faber, Catharina Gerritdina; Van Nes, Sonja Ingrid; Jacobs, Bart Casper; Van Doorn, Pieter Antoon; Van Koningsveld, Rinske; Cornblath, David; Van Der Kooi, Anneke Jelly; Cats, Elisabeth Aviva; Van Den Berg, Leonard Hendrik; Notermans, Nicolette Claudia; Van Der Pol, Willem Lodewijk; Hermans, Mieke Catharina Elisabeth; Van Der Beek, Nadine Anna Maria Elisabeth; Gorson, Kenneth Craig; Eurelings, Marijke; Engelsman, Jeroen; Boot, Hendrik; Meijer, Ronaldus Jacobus; Lauria, Giuseppe; Tennant, Alan; Merkies, Ingemar Sergio José.

In: Brain, Vol. 135, No. 5, 2012, p. 1639-1649.

Research output: Contribution to journalArticle

Vanhoutte, EK, Faber, CG, Van Nes, SI, Jacobs, BC, Van Doorn, PA, Van Koningsveld, R, Cornblath, D, Van Der Kooi, AJ, Cats, EA, Van Den Berg, LH, Notermans, NC, Van Der Pol, WL, Hermans, MCE, Van Der Beek, NAME, Gorson, KC, Eurelings, M, Engelsman, J, Boot, H, Meijer, RJ, Lauria, G, Tennant, A & Merkies, ISJ 2012, 'Modifying the Medical Research Council grading system through Rasch analyses', Brain, vol. 135, no. 5, pp. 1639-1649. https://doi.org/10.1093/brain/awr318
Vanhoutte EK, Faber CG, Van Nes SI, Jacobs BC, Van Doorn PA, Van Koningsveld R et al. Modifying the Medical Research Council grading system through Rasch analyses. Brain. 2012;135(5):1639-1649. https://doi.org/10.1093/brain/awr318
Vanhoutte, Els Karla ; Faber, Catharina Gerritdina ; Van Nes, Sonja Ingrid ; Jacobs, Bart Casper ; Van Doorn, Pieter Antoon ; Van Koningsveld, Rinske ; Cornblath, David ; Van Der Kooi, Anneke Jelly ; Cats, Elisabeth Aviva ; Van Den Berg, Leonard Hendrik ; Notermans, Nicolette Claudia ; Van Der Pol, Willem Lodewijk ; Hermans, Mieke Catharina Elisabeth ; Van Der Beek, Nadine Anna Maria Elisabeth ; Gorson, Kenneth Craig ; Eurelings, Marijke ; Engelsman, Jeroen ; Boot, Hendrik ; Meijer, Ronaldus Jacobus ; Lauria, Giuseppe ; Tennant, Alan ; Merkies, Ingemar Sergio José. / Modifying the Medical Research Council grading system through Rasch analyses. In: Brain. 2012 ; Vol. 135, No. 5. pp. 1639-1649.
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AU - Vanhoutte, Els Karla

AU - Faber, Catharina Gerritdina

AU - Van Nes, Sonja Ingrid

AU - Jacobs, Bart Casper

AU - Van Doorn, Pieter Antoon

AU - Van Koningsveld, Rinske

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AU - Van Der Kooi, Anneke Jelly

AU - Cats, Elisabeth Aviva

AU - Van Den Berg, Leonard Hendrik

AU - Notermans, Nicolette Claudia

AU - Van Der Pol, Willem Lodewijk

AU - Hermans, Mieke Catharina Elisabeth

AU - Van Der Beek, Nadine Anna Maria Elisabeth

AU - Gorson, Kenneth Craig

AU - Eurelings, Marijke

AU - Engelsman, Jeroen

AU - Boot, Hendrik

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AU - Tennant, Alan

AU - Merkies, Ingemar Sergio José

PY - 2012

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N2 - The Medical Research Council grading system has served through decades for the evaluation of muscle strength and has been recognized as a cardinal feature of daily neurological, rehabilitation and general medicine examination of patients, despite being respectfully criticized due to the unequal width of its response options. No study has systematically examined, through modern psychometric approach, whether physicians are able to properly use the Medical Research Council grades. The objectives of this study were: (i) to investigate physicians' ability to discriminate among the Medical Research Council categories in patients with different neuromuscular disorders and with various degrees of weakness through thresholds examination using Rasch analysis as a modern psychometric method; (ii) to examine possible factors influencing physicians' ability to apply the Medical Research Council categories through differential item function analyses; and (iii) to examine whether the widely used Medical Research Council 12 muscles sum score in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy would meet Rasch model's expectations. A total of 1065 patients were included from nine cohorts with the following diseases: Guillain-Barré syndrome (n=480); myotonic dystrophy type-1 (n=169); chronic inflammatory demyelinating polyradiculoneuropathy (n=139); limb-girdle muscular dystrophy (n=105); multifocal motor neuropathy (n=102); Pompe's disease (n=62) and monoclonal gammopathy of undetermined related polyneuropathy (n=8). Medical Research Council data of 72 muscles were collected. Rasch analyses were performed on Medical Research Council data for each cohort separately and after pooling data at the muscle level to increase category frequencies, and on the Medical Research Council sum score in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. Disordered thresholds were demonstrated in 74-79 of the muscles examined, indicating physicians' inability to discriminate between most Medical Research Council categories. Factors such as physicians' experience or illness type did not influence these findings. Thresholds were restored after rescoring the Medical Research Council grades from six to four options (0, paralysis; 1, severe weakness; 2, slight weakness; 3, normal strength). The Medical Research Council sum score acceptably fulfilled Rasch model expectations after rescoring the response options and creating subsets to resolve local dependency and item bias on diagnosis. In conclusion, a modified, Rasch-built four response category Medical Research Council grading system is proposed, resolving clinicians' inability to differentiate among its original response categories and improving clinical applicability. A modified Medical Research Council sum score at the interval level is presented and is recommended for future studies in Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.

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