Abstract
A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.
Original language | English (US) |
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Pages (from-to) | 451-452 |
Number of pages | 2 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 11 |
Issue number | 4 |
DOIs | |
State | Published - Feb 26 2001 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry