Modified look-locker inversion recovery T1 mapping indices: Assessment of accuracy and reproducibility between magnetic resonance scanners

Fabio S. Raman, Nadine Kawel-Boehm, Neville Gai, Melanie Freed, Jing Han, Chia Ying Liu, Joao Lima, David A. Bluemke, Songtao Liu

Research output: Contribution to journalArticle

Abstract

Background: Cardiovascular magnetic resonance (CMR) T1 mapping indices, such as T1 time and partition coefficient (λ), have shown potential to assess diffuse myocardial fibrosis. The purpose of this study was to investigate how scanner and field strength variation affect the accuracy and precision/reproducibility of T1 mapping indices. Methods. CMR studies were performed on two 1.5T and three 3T scanners. Eight phantoms were made to mimic the T1/T2 of pre- and post-contrast myocardium and blood at 1.5T and 3T. T1 mapping using MOLLI was performed with simulated heart rate of 40-100 bpm. Inversion recovery spin echo (IR-SE) was the reference standard for T1 determination. Accuracy was defined as the percent error between MOLLI and IR-SE, and scan/re-scan reproducibility was defined as the relative percent mean difference between repeat MOLLI scans. Partition coefficient was estimated by ΔR1myocardium phantom/ΔR1blood phantom. Generalized linear mixed model was used to compare the accuracy and precision/reproducibility of T1 and λ across field strength, scanners, and protocols. Results: Field strength significantly affected MOLLI T1 accuracy (6.3% error for 1.5T vs. 10.8% error for 3T, p

Original languageEnglish (US)
Article number64
JournalJournal of Cardiovascular Magnetic Resonance
Volume15
Issue number1
DOIs
StatePublished - 2013

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Magnetic Resonance Spectroscopy
Linear Models
Myocardium
Fibrosis
Heart Rate

Keywords

  • Diffuse myocardial fibrosis
  • Extracellular volume fraction (ECV)
  • Modified look-locker with inversion recovery (MOLLI)
  • Partition coefficient (λ)
  • T1 mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

Cite this

Modified look-locker inversion recovery T1 mapping indices : Assessment of accuracy and reproducibility between magnetic resonance scanners. / Raman, Fabio S.; Kawel-Boehm, Nadine; Gai, Neville; Freed, Melanie; Han, Jing; Liu, Chia Ying; Lima, Joao; Bluemke, David A.; Liu, Songtao.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 15, No. 1, 64, 2013.

Research output: Contribution to journalArticle

Raman, Fabio S. ; Kawel-Boehm, Nadine ; Gai, Neville ; Freed, Melanie ; Han, Jing ; Liu, Chia Ying ; Lima, Joao ; Bluemke, David A. ; Liu, Songtao. / Modified look-locker inversion recovery T1 mapping indices : Assessment of accuracy and reproducibility between magnetic resonance scanners. In: Journal of Cardiovascular Magnetic Resonance. 2013 ; Vol. 15, No. 1.
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