Modified cine inversion recovery pulse sequence for the quantification of myocardial T1 and gadolinium partition coefficient

Matteo Milanesi, Andrea Barison, Vincenzo Positano, Pier Giorgio Masci, Daniele De Marchi, Luca Marinelli, Christopher J. Hardy, Thomas K. Foo, Luigi Landini, Massimo Lombardi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To optimize and validate a modified cine inversion recovery sequence (MCine-IR) for myocardial T1 quantification and gadolinium partition coefficient (λGd) estimation at 1.5 T. Materials and Methods: The original version of the cine inversion recovery sequence was modified to allow fully transverse magnetization recovery between two successive inversion pulses. Sixty heart phases were acquired from a number of heart cycles determined on a patient heart rate basis. Phantom studies were carried out to find the optimal effective TR for myocardial and blood pool T1 quantifications in pre- and postcontrast studies. Four patients with myocardial infarct (MI) and 22 dilated cardiomyopathy (DCM) were investigated, as well as 11 healthy subjects used as controls. Results: Effective TR was identified to be 5000 msec and 2000 msec, respectively, for pre- and postcontrast studies. A longer precontrast (948 ± 102 msec) and shorter postcontrast (348 ± 27 msec) T1 in ischemic patients relative to DCM (815 ± 98 msec, P = 0.03 and 409 ± 42 msec, P = 0.001) were noted in delayed enhancement (DE) areas. In MI patients λGd resulted higher than in DCM in DE areas (609 ± 167 vs. 422 ± 52, P = 0.01) but lower in segments not exhibiting DE (355 ± 100 vs. 398 ± 54, P = 0.02). Conclusion: It was feasible to measure T1 and λGd with MCine-IR and the results were in good agreement with the literature. J. Magn. Reson. Imaging 2013;37:109-118. © 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number1
StatePublished - Jan 2013
Externally publishedYes


  • cine inversion recovery
  • gadolinium partition coefficient
  • myocardium
  • T1 quantification

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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