MODIFIED BEELER-REUTER MODEL YIELDS IMPROVED SIMULATION OF MYOCARDIAL ACTION POTENTIALS.

D. J. Mogul, N. V. Thakor, J. R. McCullough, G. A. Myers, R. E. TenEick, D. H. Singer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Beeler and Reuter (BR) model is limited because it does not account for (1) the effects of extracellular potassium ( left bracket K// plus right bracket //o ) on potassium permeability (P//K ), (2) the contribution of an electrogenic Na** plus K** plus pump current, (3) the effects of restricted diffusion on left bracket K** plus right bracket //o , and (4) the dependence of repolarization currents on left bracket K** plus right bracket //o . The authors have modified the BR model by incorporating equations derived from experimental studies on human and animal heart muscle to account for these factors and have thereby improved the accuracy with which cardiac action potentials can be modeled. These modifications permit the simulation and prediction of experimentally observed changes in diastolic potential and action potential duration of mammalian ventricular muscle at various bulk K** plus concentrations during stimulation at several frequencies.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
EditorsKenneth L. Ripley
PublisherIEEE
Pages159-162
Number of pages4
ISBN (Print)0818605472
StatePublished - Dec 1 1984
Externally publishedYes

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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