MODIFICATION OF WILEY-MCLAREN TOF ANALYZERS FOR LASER DESORPTION.

James K. Olthoff, Ihor Lys, Plamen Demirev, Robert J. Cotter

Research output: Contribution to journalArticlepeer-review

Abstract

Conversion of Wiley-McLaren Type TOF instruments for laser desorption is described, including laser optics, timing circuitry, postacceleration detection for high mass and data acquisition. Results are shown to illustrate signal averaging capabilities, detection limits and high mass measurements. It is shown that as with all time-of-flight instruments, sensitivity is improved by the high ion transmission of the analyzer and the ability to observe all ions (of every mass) from a single desorption event. As improvements in resolution for time of flight instruments progress and larger mass ranges are explored, the use of this analyzer will continue to increase.

Original languageEnglish (US)
Pages (from-to)93-115
Number of pages23
JournalAnalytical Instrumentation
Volume16
Issue number1
StatePublished - Mar 1 1987

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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