Modification of the side chain of micromolide, an anti-tuberculosis natural product

Hai Yuan, Rong He, Baojie Wan, Yuehong Wang, Guido F. Pauli, Scott G. Franzblau, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.

Original languageEnglish (US)
Pages (from-to)5311-5315
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number19
DOIs
StatePublished - Oct 1 2008

Keywords

  • Lactone
  • Micromolide
  • Natural product
  • SAR
  • Tuberculosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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