Modification of the side chain of micromolide, an anti-tuberculosis natural product

Hai Yuan; Rong He; Baojie Wan; Yuehong Wang; Guido F. Pauli; Scott G. Franzblau; Alan P. Kozikowski

doi:10.1016/j.bmcl.2008.08.027

Modification of the side chain of micromolide, an anti-tuberculosis natural product

Hai Yuan, Rong He, Baojie Wan, Yuehong Wang, Guido F. Pauli, Scott G. Franzblau, Alan P. Kozikowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.

Original language	English (US)
Pages (from-to)	5311-5315
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2008.08.027
State	Published - Oct 1 2008

Keywords

Lactone
Micromolide
Natural product
SAR
Tuberculosis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.08.027

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abstract = "This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.",

keywords = "Lactone, Micromolide, Natural product, SAR, Tuberculosis",

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AU - He, Rong

AU - Wan, Baojie

AU - Wang, Yuehong

AU - Pauli, Guido F.

AU - Franzblau, Scott G.

AU - Kozikowski, Alan P.

PY - 2008/10/1

Y1 - 2008/10/1

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AB - This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.

KW - Lactone

KW - Micromolide

KW - Natural product

KW - SAR

KW - Tuberculosis

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Modification of the side chain of micromolide, an anti-tuberculosis natural product

Abstract

Keywords

ASJC Scopus subject areas

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