Modification of the side chain of micromolide, an anti-tuberculosis natural product

Hai Yuan, Rong He, Baojie Wan, Yuehong Wang, Guido F. Pauli, Scott G. Franzblau, Alan P. Kozikowski

Research output: Contribution to journalArticle

Abstract

This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.

Original languageEnglish (US)
Pages (from-to)5311-5315
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number19
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Fingerprint

Biological Products
Tuberculosis
micromolide

Keywords

  • Lactone
  • Micromolide
  • Natural product
  • SAR
  • Tuberculosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Yuan, H., He, R., Wan, B., Wang, Y., Pauli, G. F., Franzblau, S. G., & Kozikowski, A. P. (2008). Modification of the side chain of micromolide, an anti-tuberculosis natural product. Bioorganic and Medicinal Chemistry Letters, 18(19), 5311-5315. https://doi.org/10.1016/j.bmcl.2008.08.027

Modification of the side chain of micromolide, an anti-tuberculosis natural product. / Yuan, Hai; He, Rong; Wan, Baojie; Wang, Yuehong; Pauli, Guido F.; Franzblau, Scott G.; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 19, 01.10.2008, p. 5311-5315.

Research output: Contribution to journalArticle

Yuan, H, He, R, Wan, B, Wang, Y, Pauli, GF, Franzblau, SG & Kozikowski, AP 2008, 'Modification of the side chain of micromolide, an anti-tuberculosis natural product', Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 19, pp. 5311-5315. https://doi.org/10.1016/j.bmcl.2008.08.027
Yuan, Hai ; He, Rong ; Wan, Baojie ; Wang, Yuehong ; Pauli, Guido F. ; Franzblau, Scott G. ; Kozikowski, Alan P. / Modification of the side chain of micromolide, an anti-tuberculosis natural product. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 19. pp. 5311-5315.
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