Modification of ion homeostasis by lipid peroxidation: Roles in neuronal degeneration and adaptive plasticity

Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

Oxyradicals attack double bonds of unsaturated fatty acids in cell membranes in a process called membrane lipid peroxidation (MLP). This process occurs in many different acute and chronic neurodegenerative conditions, and to a lesser extent during normal physiological activity in neuronal circuits. It can modify neurotransmitter release and uptake, ion-channel activity, the function of ion-motive ATPases and glucose transporters, and the coupling of cell-surface receptors to GTP-binding proteins. MLP can also impair mitochondrial function and promote a cascade of events that culminates in apoptotic cell death. The lipid peroxidation product 4-hydroxynonenal might play a central role in MLP-induced alterations in plasma membrane and mitochondrial protein functions. The modification of processes such as outgrowth of neurites and long-term potentiation of synaptic transmission by agents that suppress or promote MLP suggests roles for subtoxic levels of MLP in neuronal plasticity.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalTrends in Neurosciences
Volume21
Issue number2
DOIs
StatePublished - Feb 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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