Modification of hybrid responsiveness in the local graft-versus-host reaction by injection of parental lymphocytes

Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

The local graft-versus-host reaction in F! hybrid rats, assayed by popliteal lymph node enlargement, is specifically depressed by pretreating the host with parental lymphocytes. The conditions for demonstrating specific depression are injection of a small dose of parental lymphocytes and assay 7 days later. Pretreatment with cells from thymus and bone marrow is ineffective, as is pretreatment with purified B lymphocytes. The structures which stimulate the suppressed response of F! hybrids are not present on parental B lymphocytes.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalTransplantation
Volume20
Issue number3
DOIs
StatePublished - Sep 1975

ASJC Scopus subject areas

  • Transplantation

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