Abstract
SETTING: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. OBJECTIVE: To assess the association between novel modifiable risk factors and TB in Indian children. DESIGN: Cases were children aged ≤5 years with c onfirmed/probable TB based on World Health Organization definitions (definition 1). Controls were healthy children aged ≤5 years. Logistic regression was performed to estimate the adjusted odds ratio (aOR) of being a TB case given exposure, including indoor air pollution (IAP; exposure to tobacco smoke and/or biomass fuels) and vitamin D deficiency. Cases were re-analyzed according to a new consensus research definition of pediatric TB (definition 2). RESULTS: Sixty cases and 118 controls were enrolled.Both groups had high levels of vitamin D deficiency (55% vs. 50%, P = 0.53). In multivariable analysis, TB was associated with household TB exposure (aOR 25.41, 95%CI 7.03-91.81), household food insecurity (aOR 11.55, 95%CI 3.33-40.15) and IAP exposure (aOR 2.67, 95%CI 1.02-6.97), but not vitamin D deficiency (aOR 1.00, 95%CI 0.38-2.66). Use of definition 2 reduced the number of cases to 25. In multivariate analysis, TB exposure, household food insecurity and IAP remained associated with TB. CONCLUSIONS: Household TB exposure, exposure to IAP and household food insecurity were independently associated with pediatric TB.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 198-204 |
| Number of pages | 7 |
| Journal | International Journal of Tuberculosis and Lung Disease |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2014 |
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Keywords
- Household food insecurity
- Indoor air pollution
- Pediatric tuberculosis
- Vitamin D deficiency
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases
Cite this
Modifiable risk factors associated with tuberculosis disease in children in Pune, India. / Jubulis, Jennifer; Kinikar, A.; Ithape, M.; Khandave, M.; Dixit, S.; Hotalkar, S.; Kulkarni, V.; Mave, Vidya; Gupte, Nikhil; Kagal, A.; Jain, Sanjay; Bharadwaj, R.; Gupta, Amita.
In: International Journal of Tuberculosis and Lung Disease, Vol. 18, No. 2, 01.02.2014, p. 198-204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modifiable risk factors associated with tuberculosis disease in children in Pune, India
AU - Jubulis, Jennifer
AU - Kinikar, A.
AU - Ithape, M.
AU - Khandave, M.
AU - Dixit, S.
AU - Hotalkar, S.
AU - Kulkarni, V.
AU - Mave, Vidya
AU - Gupte, Nikhil
AU - Kagal, A.
AU - Jain, Sanjay
AU - Bharadwaj, R.
AU - Gupta, Amita
PY - 2014/2/1
Y1 - 2014/2/1
N2 - SETTING: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. OBJECTIVE: To assess the association between novel modifiable risk factors and TB in Indian children. DESIGN: Cases were children aged ≤5 years with c onfirmed/probable TB based on World Health Organization definitions (definition 1). Controls were healthy children aged ≤5 years. Logistic regression was performed to estimate the adjusted odds ratio (aOR) of being a TB case given exposure, including indoor air pollution (IAP; exposure to tobacco smoke and/or biomass fuels) and vitamin D deficiency. Cases were re-analyzed according to a new consensus research definition of pediatric TB (definition 2). RESULTS: Sixty cases and 118 controls were enrolled.Both groups had high levels of vitamin D deficiency (55% vs. 50%, P = 0.53). In multivariable analysis, TB was associated with household TB exposure (aOR 25.41, 95%CI 7.03-91.81), household food insecurity (aOR 11.55, 95%CI 3.33-40.15) and IAP exposure (aOR 2.67, 95%CI 1.02-6.97), but not vitamin D deficiency (aOR 1.00, 95%CI 0.38-2.66). Use of definition 2 reduced the number of cases to 25. In multivariate analysis, TB exposure, household food insecurity and IAP remained associated with TB. CONCLUSIONS: Household TB exposure, exposure to IAP and household food insecurity were independently associated with pediatric TB.
AB - SETTING: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. OBJECTIVE: To assess the association between novel modifiable risk factors and TB in Indian children. DESIGN: Cases were children aged ≤5 years with c onfirmed/probable TB based on World Health Organization definitions (definition 1). Controls were healthy children aged ≤5 years. Logistic regression was performed to estimate the adjusted odds ratio (aOR) of being a TB case given exposure, including indoor air pollution (IAP; exposure to tobacco smoke and/or biomass fuels) and vitamin D deficiency. Cases were re-analyzed according to a new consensus research definition of pediatric TB (definition 2). RESULTS: Sixty cases and 118 controls were enrolled.Both groups had high levels of vitamin D deficiency (55% vs. 50%, P = 0.53). In multivariable analysis, TB was associated with household TB exposure (aOR 25.41, 95%CI 7.03-91.81), household food insecurity (aOR 11.55, 95%CI 3.33-40.15) and IAP exposure (aOR 2.67, 95%CI 1.02-6.97), but not vitamin D deficiency (aOR 1.00, 95%CI 0.38-2.66). Use of definition 2 reduced the number of cases to 25. In multivariate analysis, TB exposure, household food insecurity and IAP remained associated with TB. CONCLUSIONS: Household TB exposure, exposure to IAP and household food insecurity were independently associated with pediatric TB.
KW - Household food insecurity
KW - Indoor air pollution
KW - Pediatric tuberculosis
KW - Vitamin D deficiency
UR - http://www.scopus.com/inward/record.url?scp=84892619600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892619600&partnerID=8YFLogxK
U2 - 10.5588/ijtld.13.0314
DO - 10.5588/ijtld.13.0314
M3 - Article
C2 - 24429313
AN - SCOPUS:84892619600
VL - 18
SP - 198
EP - 204
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
SN - 1027-3719
IS - 2
ER -