Modic-Typ-1-Endplattenveränderungen

Detektionsrate mittels fettgesättigten, flüssigkeitssensitiven MRT-Sequenzen

Translated title of the contribution: Modic Type 1 Changes: Detection Performance of Fat-Suppressed Fluid-Sensitive MRI Sequences

Tim Finkenstaedt, Filippo Del Grande, Nicolae Bolog, Nils Ulrich, Sina Tok, Orpheus Kolokythas, Johann Steurer, Gustav Andreisek, Sebastian Winklhofer

Research output: Contribution to journalArticle

Abstract

Purpose To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI. Materials and Methods Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated. We recorded the presence (yes/no) and extension (i. e., Likert-scale of height, volume, and end-plate extension) of Modic I changes in T1w/T2w sequences and compared the results to fat-suppressed fluid-sensitive sequences (McNemar/Wilcoxon-signed-rank test). Results Fat-suppressed fluid-sensitive sequences revealed significantly more Modic I changes compared to T1w/T2w sequences (156 vs. 93 segments, respectively; p < 0.001). The extension of Modic I changes in fat-suppressed fluid-sensitive sequences was significantly larger compared to T1w/T2w sequences (height: 2.53 ± 0.82 vs. 2.27 ± 0.79, volume: 2.35 ± 0.76 vs. 2.1 ± 0.65, end-plate: 2.46 ± 0.76 vs. 2.19 ± 0.81), (p < 0.05). Modic I changes that were only visible in fat-suppressed fluid-sensitive sequences but not in T1w/T2w sequences were significantly smaller compared to Modic I changes that were also visible in T1w/T2w sequences (p < 0.05). Conclusion In conclusion, fat-suppressed fluid-sensitive MRI sequences revealed significantly more Modic I end-plate changes and demonstrated a greater extent compared to standard T1w/T2w imaging. Key Points When the Modic classification was defined in 1988, T2w sequences were heavily T2-weighted and thus virtually fat-suppressed. Nowadays, the bright fat signal in T2w images masks edema-like changes. The conventional definition of Modic I changes is not fully applicable anymore. Fat-suppressed fluid-sensitive MRI sequences revealed more/greater extent of Modic I changes. Citation Format Finkenstaedt T, Del Grande F, Bolog N et al. Modic Type 1 Changes: Detection Performance of Fat-Suppressed Fluid-Sensitive MRI Sequences. Fortschr Röntgenstr 2017; DOI: 10.1055/s-0043-118130

Original languageGerman
JournalRoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren
DOIs
StateAccepted/In press - Nov 27 2017
Externally publishedYes

Fingerprint

Fats
Masks
Nonparametric Statistics
Edema
Spine

Keywords

  • bone diseases
  • magnetic resonance imaging
  • modic
  • sensitivity and specificity
  • spinal canal

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Modic-Typ-1-Endplattenveränderungen : Detektionsrate mittels fettgesättigten, flüssigkeitssensitiven MRT-Sequenzen. / Finkenstaedt, Tim; Del Grande, Filippo; Bolog, Nicolae; Ulrich, Nils; Tok, Sina; Kolokythas, Orpheus; Steurer, Johann; Andreisek, Gustav; Winklhofer, Sebastian.

In: RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren, 27.11.2017.

Research output: Contribution to journalArticle

Finkenstaedt, Tim ; Del Grande, Filippo ; Bolog, Nicolae ; Ulrich, Nils ; Tok, Sina ; Kolokythas, Orpheus ; Steurer, Johann ; Andreisek, Gustav ; Winklhofer, Sebastian. / Modic-Typ-1-Endplattenveränderungen : Detektionsrate mittels fettgesättigten, flüssigkeitssensitiven MRT-Sequenzen. In: RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren. 2017.
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abstract = "Purpose To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI. Materials and Methods Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated. We recorded the presence (yes/no) and extension (i. e., Likert-scale of height, volume, and end-plate extension) of Modic I changes in T1w/T2w sequences and compared the results to fat-suppressed fluid-sensitive sequences (McNemar/Wilcoxon-signed-rank test). Results Fat-suppressed fluid-sensitive sequences revealed significantly more Modic I changes compared to T1w/T2w sequences (156 vs. 93 segments, respectively; p < 0.001). The extension of Modic I changes in fat-suppressed fluid-sensitive sequences was significantly larger compared to T1w/T2w sequences (height: 2.53 ± 0.82 vs. 2.27 ± 0.79, volume: 2.35 ± 0.76 vs. 2.1 ± 0.65, end-plate: 2.46 ± 0.76 vs. 2.19 ± 0.81), (p < 0.05). Modic I changes that were only visible in fat-suppressed fluid-sensitive sequences but not in T1w/T2w sequences were significantly smaller compared to Modic I changes that were also visible in T1w/T2w sequences (p < 0.05). Conclusion In conclusion, fat-suppressed fluid-sensitive MRI sequences revealed significantly more Modic I end-plate changes and demonstrated a greater extent compared to standard T1w/T2w imaging. Key Points When the Modic classification was defined in 1988, T2w sequences were heavily T2-weighted and thus virtually fat-suppressed. Nowadays, the bright fat signal in T2w images masks edema-like changes. The conventional definition of Modic I changes is not fully applicable anymore. Fat-suppressed fluid-sensitive MRI sequences revealed more/greater extent of Modic I changes. Citation Format Finkenstaedt T, Del Grande F, Bolog N et al. Modic Type 1 Changes: Detection Performance of Fat-Suppressed Fluid-Sensitive MRI Sequences. Fortschr R{\"o}ntgenstr 2017; DOI: 10.1055/s-0043-118130",
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author = "Tim Finkenstaedt and {Del Grande}, Filippo and Nicolae Bolog and Nils Ulrich and Sina Tok and Orpheus Kolokythas and Johann Steurer and Gustav Andreisek and Sebastian Winklhofer",
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T2 - Detektionsrate mittels fettgesättigten, flüssigkeitssensitiven MRT-Sequenzen

AU - Finkenstaedt, Tim

AU - Del Grande, Filippo

AU - Bolog, Nicolae

AU - Ulrich, Nils

AU - Tok, Sina

AU - Kolokythas, Orpheus

AU - Steurer, Johann

AU - Andreisek, Gustav

AU - Winklhofer, Sebastian

PY - 2017/11/27

Y1 - 2017/11/27

N2 - Purpose To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI. Materials and Methods Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated. We recorded the presence (yes/no) and extension (i. e., Likert-scale of height, volume, and end-plate extension) of Modic I changes in T1w/T2w sequences and compared the results to fat-suppressed fluid-sensitive sequences (McNemar/Wilcoxon-signed-rank test). Results Fat-suppressed fluid-sensitive sequences revealed significantly more Modic I changes compared to T1w/T2w sequences (156 vs. 93 segments, respectively; p < 0.001). The extension of Modic I changes in fat-suppressed fluid-sensitive sequences was significantly larger compared to T1w/T2w sequences (height: 2.53 ± 0.82 vs. 2.27 ± 0.79, volume: 2.35 ± 0.76 vs. 2.1 ± 0.65, end-plate: 2.46 ± 0.76 vs. 2.19 ± 0.81), (p < 0.05). Modic I changes that were only visible in fat-suppressed fluid-sensitive sequences but not in T1w/T2w sequences were significantly smaller compared to Modic I changes that were also visible in T1w/T2w sequences (p < 0.05). Conclusion In conclusion, fat-suppressed fluid-sensitive MRI sequences revealed significantly more Modic I end-plate changes and demonstrated a greater extent compared to standard T1w/T2w imaging. Key Points When the Modic classification was defined in 1988, T2w sequences were heavily T2-weighted and thus virtually fat-suppressed. Nowadays, the bright fat signal in T2w images masks edema-like changes. The conventional definition of Modic I changes is not fully applicable anymore. Fat-suppressed fluid-sensitive MRI sequences revealed more/greater extent of Modic I changes. Citation Format Finkenstaedt T, Del Grande F, Bolog N et al. Modic Type 1 Changes: Detection Performance of Fat-Suppressed Fluid-Sensitive MRI Sequences. Fortschr Röntgenstr 2017; DOI: 10.1055/s-0043-118130

AB - Purpose To assess the performance of fat-suppressed fluid-sensitive MRI sequences compared to T1-weighted (T1w) / T2w sequences for the detection of Modic 1 end-plate changes on lumbar spine MRI. Materials and Methods Sagittal T1w, T2w, and fat-suppressed fluid-sensitive MRI images of 100 consecutive patients (consequently 500 vertebral segments; 52 female, mean age 74 ± 7.4 years; 48 male, mean age 71 ± 6.3 years) were retrospectively evaluated. We recorded the presence (yes/no) and extension (i. e., Likert-scale of height, volume, and end-plate extension) of Modic I changes in T1w/T2w sequences and compared the results to fat-suppressed fluid-sensitive sequences (McNemar/Wilcoxon-signed-rank test). Results Fat-suppressed fluid-sensitive sequences revealed significantly more Modic I changes compared to T1w/T2w sequences (156 vs. 93 segments, respectively; p < 0.001). The extension of Modic I changes in fat-suppressed fluid-sensitive sequences was significantly larger compared to T1w/T2w sequences (height: 2.53 ± 0.82 vs. 2.27 ± 0.79, volume: 2.35 ± 0.76 vs. 2.1 ± 0.65, end-plate: 2.46 ± 0.76 vs. 2.19 ± 0.81), (p < 0.05). Modic I changes that were only visible in fat-suppressed fluid-sensitive sequences but not in T1w/T2w sequences were significantly smaller compared to Modic I changes that were also visible in T1w/T2w sequences (p < 0.05). Conclusion In conclusion, fat-suppressed fluid-sensitive MRI sequences revealed significantly more Modic I end-plate changes and demonstrated a greater extent compared to standard T1w/T2w imaging. Key Points When the Modic classification was defined in 1988, T2w sequences were heavily T2-weighted and thus virtually fat-suppressed. Nowadays, the bright fat signal in T2w images masks edema-like changes. The conventional definition of Modic I changes is not fully applicable anymore. Fat-suppressed fluid-sensitive MRI sequences revealed more/greater extent of Modic I changes. Citation Format Finkenstaedt T, Del Grande F, Bolog N et al. Modic Type 1 Changes: Detection Performance of Fat-Suppressed Fluid-Sensitive MRI Sequences. Fortschr Röntgenstr 2017; DOI: 10.1055/s-0043-118130

KW - bone diseases

KW - magnetic resonance imaging

KW - modic

KW - sensitivity and specificity

KW - spinal canal

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