Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells

Devrim Pesen, Jan H. Hoh

Research output: Contribution to journalArticlepeer-review

Abstract

The cortical cytoskeleton of vascular endothelial cells plays an important role in responding to mechanical stimuli and controlling the distribution of cell surface proteins. Here, we have used atomic force microscopy to visualize the dynamics of cortical cytoskeleton in living bovine pulmonary artery endothelial cells. We demonstrate that the cortical cytoskeleton, organized as a complex polygonal mesh, is highly dynamic and shows two modes of remodeling: intact-boundary-mode where mesh element boundaries remain intact but move at ∼0.08 μm/min allowing the mesh element to change shape, and altered-boundary-mode where new mesh boundaries form and existing ones disappear.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalFEBS Letters
Volume579
Issue number2
DOIs
StatePublished - Jan 17 2005

Keywords

  • Atomic force microscopy
  • Cytoskeletal dynamics
  • Endothelial cell
  • Mechanotransduction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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