Moderne arzneimittel-therapie der altersabhängigen makuladegeneration

Translated title of the contribution: Modern pharmacotherapy of age-related macular degeneration

F. G. Holz, H. M. Helb, A. Bindewald-Wittich, H. P.N. Scholl

Research output: Contribution to journalArticle

Abstract

Age-related macular degeneration (AMD) is now the most common cause for blind registration in all developed countries. Epidemiologic data indicate that there are 4.5 mio affected in Germany with constant increase in incidence and prevalence with subsequent considerable health economic implications. Late manifestations of the disease result in the inability to read and to perform daily tasks. Therefore, there is an urgent need for efficacious prophylactic and therapeutic measures to prevent irreversible loss of central vision. Based on a better understanding of the underlying molecular mechanisms new therapeutic approaches have been brought forward and expand previous approaches such as thermal laser surgery or photodynamic therapy. Repeated intravitreal injection of anti-VEGF (vascular endothelial growth factor) agents as well as cosrticosteroids have a beneficial effect on growth and permeability of neovascular membranes. The risk for progression from early to late stages of AMD can be reduced with certain antioxidative preparations (AREDS medication) in presence of defined funduscopic signs. Early diagnosis is key for all currently availabe interventions since a beneficial effect can only be achieved in early stages of the disease process.

Translated title of the contributionModern pharmacotherapy of age-related macular degeneration
Original languageGerman
Pages (from-to)192-198
Number of pages7
JournalInternist
Volume47
Issue number2
DOIs
StatePublished - Feb 1 2006

Keywords

  • Age-related macular degeneration
  • Anti-angiogenesis
  • Choroidal neovascularization
  • Corticosteroids
  • VEGF

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Holz, F. G., Helb, H. M., Bindewald-Wittich, A., & Scholl, H. P. N. (2006). Moderne arzneimittel-therapie der altersabhängigen makuladegeneration. Internist, 47(2), 192-198. https://doi.org/10.1007/s00108-005-1545-z