Moderate to severe, but not mild, maternal anemia is associated with increased risk of small-for-gestational-age outcomes

Naoko Kozuki, Anne C. Lee, Joanne Katz

Research output: Contribution to journalArticle

Abstract

Anemia is highly prevalent globally, estimated at 40-50% in women of reproductive age. Prior studies have produced inconclusive evidence as to the association between maternal anemia and intrauterine growth restriction (IUGR). We conducted a systematic review of the literature containing associations between maternal anemia and small for gestational age (SGA) outcomes (as a proxy for IUGR). A meta-analysis was performed to pool associations, categorized by the hemoglobin cutoffs presented by the authors. We identified 12 studies reporting associations between maternal anemia and SGA. For the metaanalysis, there were 7 associations with a hemoglobin cutoff <110 g/L, 7 with a cutoff <100 g/L, and 5 with a cutoff <90 or <80 g/L. Although the <110- and <100-g/L categories showed no significant relationship with SGA, the

Original languageEnglish (US)
Pages (from-to)358-362
Number of pages5
JournalJournal of Nutrition
Volume142
Issue number2
DOIs
StatePublished - Feb 1 2012

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Gestational Age
Anemia
Mothers
Hemoglobins
Proxy
Growth
Meta-Analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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Moderate to severe, but not mild, maternal anemia is associated with increased risk of small-for-gestational-age outcomes. / Kozuki, Naoko; Lee, Anne C.; Katz, Joanne.

In: Journal of Nutrition, Vol. 142, No. 2, 01.02.2012, p. 358-362.

Research output: Contribution to journalArticle

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