TY - JOUR
T1 - Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction
AU - Serebruany, Victor L.
AU - Lowry, David R.
AU - Fuzailov, Sergei Y.
AU - Levine, Douglas J.
AU - O'Connor, Christopher M.
AU - Gurbel, Paul A.
N1 - Funding Information:
This study was supported in part by Boehringer Mannheim, GmbH, and Medtronic, Inc. We are indebted to the staff of the emergency departments and critical care units of the St. Agnes and the Union Memorial Hospitals (Baltimore, MD, USA).
PY - 2000
Y1 - 2000
N2 - Moderate alcohol consumption (MAC) and platelet inhibition have been independently associated with a reduced risk for the development of acute myocardial infarction (AMI). The effects of MAC on the initial platelet status in patients presenting with AMI are not elucidated. Here we sought to define the effects of MAC on platelet characteristics in AMI patients before applying any reperfusion strategies. The study was designed as an analysis within the cohort study in 23 patients with AMI enrolled in the GUSTO-III. Platelets were investigated by different techniques, including aggregometry, flow cytometry, and ELISA. MAC patients exhibited mild, but consistent, inhibition of platelet aggregability, surface receptor expression, and released substances as compared to non-alcohol consuming patients. These differences were significant for 5 μM ADP (p = 0.04), 10 μM ADP-induced aggregation (p = 0.02); P-selectin (p = 0.01), and PECAM-1 (p = 0.02) platelet-bound expression. Our study confirms that moderate alcohol consumption is associated with diminished platelet activation in patients presenting with AMI. The ability of MAC to favorably modulate the pre-reperfusion platelet status in such patients is of clinical importance, and further investigation in large-scale clinical trials seem warranted.
AB - Moderate alcohol consumption (MAC) and platelet inhibition have been independently associated with a reduced risk for the development of acute myocardial infarction (AMI). The effects of MAC on the initial platelet status in patients presenting with AMI are not elucidated. Here we sought to define the effects of MAC on platelet characteristics in AMI patients before applying any reperfusion strategies. The study was designed as an analysis within the cohort study in 23 patients with AMI enrolled in the GUSTO-III. Platelets were investigated by different techniques, including aggregometry, flow cytometry, and ELISA. MAC patients exhibited mild, but consistent, inhibition of platelet aggregability, surface receptor expression, and released substances as compared to non-alcohol consuming patients. These differences were significant for 5 μM ADP (p = 0.04), 10 μM ADP-induced aggregation (p = 0.02); P-selectin (p = 0.01), and PECAM-1 (p = 0.02) platelet-bound expression. Our study confirms that moderate alcohol consumption is associated with diminished platelet activation in patients presenting with AMI. The ability of MAC to favorably modulate the pre-reperfusion platelet status in such patients is of clinical importance, and further investigation in large-scale clinical trials seem warranted.
KW - Acute myocardial infarction
KW - Alcohol
KW - Human
KW - Platelets
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U2 - 10.1023/A:1018762510842
DO - 10.1023/A:1018762510842
M3 - Article
C2 - 10728021
AN - SCOPUS:0034073331
SN - 0929-5305
VL - 9
SP - 229
EP - 234
JO - Journal of Thrombosis and Thrombolysis
JF - Journal of Thrombosis and Thrombolysis
IS - 3
ER -