Models of epilepsy in the developing and adult brain: Implications for neuroprotection

Carl E. Stafstrom, Thomas P. Sutula

Research output: Contribution to journalArticlepeer-review

Abstract

Repeated seizures cause a sequence of molecular and cellular changes in both the developing and adult brain, which may lead to intractable epilepsy. This article reviews this sequence of neuronal alterations, with emphasis on the kindling model. At each step, the opportunity exists for strategic intervention to prevent or reduce the downstream consequences of epileptogenesis and seizure-induced adverse plasticity. The concept of seizure-induced brain damage must be expanded to include behavioral and cognitive deficits, as well as structural neuronal damage and increased predisposition to seizures.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalEpilepsy and Behavior
Volume7
Issue numberSUPPL. 3
DOIs
StatePublished - Dec 2005
Externally publishedYes

Keywords

  • Epileptogenesis
  • Kindling
  • Neuronal damage
  • Plasticity
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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