Models of coxsackievirus-B3-induced myocarditis: Recent advances

De Lisa Fairweather, Noel R. Rose

Research output: Contribution to journalReview article

Abstract

Currently, animal models are available that closely resemble human myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis models fall into two major categories: direct viral damage models and virus-triggered autoimmune models. Debate focuses on whether CVB3 can cause autoimmune heart disease or whether myocardial inflammation is due to direct damage or persistence of virus. Recent findings strengthen the argument that CVB3 triggers autoimmune myocarditis in mice without the requirement for active viral replication.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalDrug Discovery Today: Disease Models
Volume1
Issue number4
DOIs
StatePublished - Dec 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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