Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.
|Original language||English (US)|
|Pages (from-to)||Unit 9.13|
|Journal||Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]|
|State||Published - Nov 2002|
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