TY - JOUR
T1 - Models of amyotrophic lateral sclerosis.
AU - Jackson, Mandy
AU - Ganel, Raquelli
AU - Rothstein, Jeffrey D.
PY - 2002/11
Y1 - 2002/11
N2 - Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.
AB - Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.
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U2 - 10.1002/0471142301.ns0913s20
DO - 10.1002/0471142301.ns0913s20
M3 - Review article
C2 - 18428572
AN - SCOPUS:45549087576
SN - 1934-8584
VL - Chapter 9
SP - Unit 9.13
JO - Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
JF - Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
ER -