Models for the Study of stroke

Thiruma V. Arumugam, Mark P. Mattson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter presents models for examining stroke-a devastating disease that represents the third leading cause of death in the United States. In focal ischemia models, the middle cerebral artery typically is occluded either permanently or temporarily to allow reperfusion. There are several different risk factors for ischemic stroke, including genetic factors, aging, hypertension, hypercholesterolemia, diabetes mellitus, atrial fibrillation, coagulation disorders, and smoking. The large variation in ethnic groups that have been studied, the variable sample size, and the dissimilar criteria in the selection of patients and controls have led to variable results, with few consistent findings. Whether hypercholesterolemia, a major risk factor for coronary heart disease, is associated with stroke is controversial and remains a matter of debate. Elevated levels of circulating cholesterol cause deposits to form inside blood vessels. Overeating, a sedentary lifestyle, smoking, and diets high in saturated and trans-fats and cholesterol and low in whole grains and vegetables increase the risk of stroke.

Original languageEnglish (US)
Title of host publicationHandbook of Models for Human Aging
PublisherElsevier Inc.
Pages947-960
Number of pages14
ISBN (Print)9780123693914
DOIs
StatePublished - 2006

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Stroke
Hypercholesterolemia
Cholesterol
Patient Selection
Smoking
Blood vessels
Vegetables
Nutrition
Medical problems
Coagulation
Sedentary Lifestyle
Hyperphagia
Middle Cerebral Artery
Deposits
Aging of materials
Fats
Ethnic Groups
Sample Size
Atrial Fibrillation
Reperfusion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Arumugam, T. V., & Mattson, M. P. (2006). Models for the Study of stroke. In Handbook of Models for Human Aging (pp. 947-960). Elsevier Inc.. https://doi.org/10.1016/B978-012369391-4/50080-1

Models for the Study of stroke. / Arumugam, Thiruma V.; Mattson, Mark P.

Handbook of Models for Human Aging. Elsevier Inc., 2006. p. 947-960.

Research output: Chapter in Book/Report/Conference proceedingChapter

Arumugam, TV & Mattson, MP 2006, Models for the Study of stroke. in Handbook of Models for Human Aging. Elsevier Inc., pp. 947-960. https://doi.org/10.1016/B978-012369391-4/50080-1
Arumugam TV, Mattson MP. Models for the Study of stroke. In Handbook of Models for Human Aging. Elsevier Inc. 2006. p. 947-960 https://doi.org/10.1016/B978-012369391-4/50080-1
Arumugam, Thiruma V. ; Mattson, Mark P. / Models for the Study of stroke. Handbook of Models for Human Aging. Elsevier Inc., 2006. pp. 947-960
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