Models for LRRK2-linked parkinsonism

Wanli W. Smith, Tianxia Li, Dejun Yang, Sarah Sushchky, Zhaohui Liu

Research output: Contribution to journalReview articlepeer-review

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD is not fully understood, but it appears to involve both genetic susceptibility and environmental factors. Treatment for PD that prevents neuronal death progression in the dopaminergic system and abnormal protein deposition in the brain is not yet available. Recently, mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified to cause autosomal-dominant late-onset PD and contribute to sporadic PD. Here, we review the recent models for LRRK2-linked Parkinsonism and their utility in studying LRRK2 neurobiology, pathogenesis, and potential therapeutics.

Original languageEnglish (US)
Article number942412
JournalParkinson's Disease
DOIs
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

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