Models for longitudinal data: A generalized estimating equation approach

S. L. Zeger, K. Y. Liang, P. S. Albert

Research output: Contribution to journalArticle

Abstract

This article discusses extensions of generalized linear models for the analysis of longitudinal data. Two approaches are considered: subject-specific (SS) models in which heterogeneity in regression parameters is explicitly modelled; and population-averaged (PA) models in which the aggregate response for the population is the focus. We use a generalized estimating equation approach to fit both classes of models for discrete and continuous outcomes. When the subject-specific parameters are assumed to follow a Gaussian distribution, simple relationships between the PA and SS parameters are available. The methods are illustrated with an analysis of data on mother's smoking and children's respiratory disease.

Original languageEnglish (US)
Pages (from-to)1049-1060
Number of pages12
JournalBiometrics
Volume44
Issue number4
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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