Modelling the social and structural determinants of tuberculosis: Opportunities and challenges

D. Pedrazzoli, D. Boccia, P. J. Dodd, K. Lönnroth, David Wesley Dowdy, A. Siroka, M. E. Kimerling, R. G. White, R. M.G.J. Houben

Research output: Contribution to journalReview article

Abstract

INTRODUCTION: Despite the close link between tuberculosis (TB) and poverty, most mathematical models of TB have not addressed underlying social and structural determinants. OBJECTIVE: To review studies employing mathematical modelling to evaluate the epidemiological impact of the structural determinants of TB. METHODS: We systematically searched PubMed and personal libraries to identify eligible articles. We extracted data on the modelling techniques employed, research question, types of structural determinants modelled and setting.RESULTS: From 232 records identified, we included eight articles published between 2008 and 2015; six employed population-based dynamic TB transmission models and two non-dynamic analytic models. Seven studies focused on proximal TB determinants (four on nutritional status, one on wealth, one on indoor air pollution, and one examined overcrowding, socioeconomic and nutritional status), and one focused on macro-economic influences.CONCLUSIONS: Few modelling studies have attempted to evaluate structural determinants of TB, resulting in key knowledge gaps. Despite the challenges of modelling such a complex system, models must broaden their scope to remain useful for policy making. Given the intersectoral nature of the interrelations between structural determinants and TB outcomes, this work will require multidisciplinary collaborations. A useful starting point would be to focus on developing relatively simple models that can strengthen our knowledge regarding the potential effect of the structural determinants on TB outcomes.

Original languageEnglish (US)
Pages (from-to)957-964
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2017

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Tuberculosis
Nutritional Status
Indoor Air Pollution
Policy Making
Population Dynamics
Poverty
PubMed
Social Class
Libraries
Research Design
Theoretical Models
Economics

Keywords

  • Mathematical modelling
  • Social determinants
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Modelling the social and structural determinants of tuberculosis : Opportunities and challenges. / Pedrazzoli, D.; Boccia, D.; Dodd, P. J.; Lönnroth, K.; Dowdy, David Wesley; Siroka, A.; Kimerling, M. E.; White, R. G.; Houben, R. M.G.J.

In: International Journal of Tuberculosis and Lung Disease, Vol. 21, No. 9, 01.09.2017, p. 957-964.

Research output: Contribution to journalReview article

Pedrazzoli, D, Boccia, D, Dodd, PJ, Lönnroth, K, Dowdy, DW, Siroka, A, Kimerling, ME, White, RG & Houben, RMGJ 2017, 'Modelling the social and structural determinants of tuberculosis: Opportunities and challenges', International Journal of Tuberculosis and Lung Disease, vol. 21, no. 9, pp. 957-964. https://doi.org/10.5588/ijtld.16.0906
Pedrazzoli, D. ; Boccia, D. ; Dodd, P. J. ; Lönnroth, K. ; Dowdy, David Wesley ; Siroka, A. ; Kimerling, M. E. ; White, R. G. ; Houben, R. M.G.J. / Modelling the social and structural determinants of tuberculosis : Opportunities and challenges. In: International Journal of Tuberculosis and Lung Disease. 2017 ; Vol. 21, No. 9. pp. 957-964.
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AU - Dowdy, David Wesley

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