Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating brain energetics

Tracy Moroz, Tharindi Hapuarachchi, Alan Bainbridge, David Price, Ernest Cady, Ether Baer, Ilias Tachtsidis, Kevin Broad, Mojgan Ezzati, Nicola J. Robertson, David Thomas, Xavier Golay, Chris E. Cooper

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXV
PublisherSpringer New York LLC
Pages339-344
Number of pages6
ISBN (Print)9781461472568
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume789
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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