TY - GEN
T1 - Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia
T2 - Simulating brain energetics
AU - Moroz, Tracy
AU - Hapuarachchi, Tharindi
AU - Bainbridge, Alan
AU - Price, David
AU - Cady, Ernest
AU - Baer, Ether
AU - Tachtsidis, Ilias
AU - Broad, Kevin
AU - Ezzati, Mojgan
AU - Robertson, Nicola J.
AU - Thomas, David
AU - Golay, Xavier
AU - Cooper, Chris E.
N1 - Funding Information:
The authors would like to thank the Wellcome Trust (088429/Z/09/Z) for the financial support of this work.
PY - 2013
Y1 - 2013
N2 - We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct.
AB - We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct.
UR - http://www.scopus.com/inward/record.url?scp=84934440067&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934440067&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-7411-1_45
DO - 10.1007/978-1-4614-7411-1_45
M3 - Conference contribution
C2 - 23852513
AN - SCOPUS:84934440067
SN - 9781461472568
T3 - Advances in Experimental Medicine and Biology
SP - 339
EP - 344
BT - Oxygen Transport to Tissue XXXV
PB - Springer New York LLC
ER -