Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes

Tharindi Hapuarachchi, Tracy Moroz, Alan Bainbridge, David Price, Ernest Cady, Esther Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J. Robertson, Ilias Tachtsidis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXV
PublisherSpringer New York LLC
Pages331-334
Number of pages4
ISBN (Print)9781461472568
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume789
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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