Abstract
We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 331-334 |
| Number of pages | 4 |
| Volume | 789 |
| ISBN (Print) | 9781461472568 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 789 |
| ISSN (Print) | 00652598 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia : Simulating pH changes. / Hapuarachchi, Tharindi; Moroz, Tracy; Bainbridge, Alan; Price, David; Cady, Ernest; Baer, Esther; Broad, Kevin; Ezzati, Mojgan; Thomas, David; Golay, Xavier; Robertson, Nicola J.; Tachtsidis, Ilias.
Advances in Experimental Medicine and Biology. Vol. 789 Springer New York LLC, 2013. p. 331-334 (Advances in Experimental Medicine and Biology; Vol. 789).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia
T2 - Simulating pH changes
AU - Hapuarachchi, Tharindi
AU - Moroz, Tracy
AU - Bainbridge, Alan
AU - Price, David
AU - Cady, Ernest
AU - Baer, Esther
AU - Broad, Kevin
AU - Ezzati, Mojgan
AU - Thomas, David
AU - Golay, Xavier
AU - Robertson, Nicola J.
AU - Tachtsidis, Ilias
PY - 2013
Y1 - 2013
N2 - We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
AB - We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
UR - http://www.scopus.com/inward/record.url?scp=84934442555&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934442555&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-7411-1_44
DO - 10.1007/978-1-4614-7411-1_44
M3 - Conference contribution
C2 - 23852512
AN - SCOPUS:84934442555
SN - 9781461472568
VL - 789
T3 - Advances in Experimental Medicine and Biology
SP - 331
EP - 334
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -