Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes

Tharindi Hapuarachchi, Tracy Moroz, Alan Bainbridge, David Price, Ernest Cady, Esther Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J. Robertson, Ilias Tachtsidis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages331-334
Number of pages4
Volume789
ISBN (Print)9781461472568
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume789
ISSN (Print)00652598

Fingerprint

Magnetic resonance spectroscopy
Brain Hypoxia-Ischemia
Metabolism
Brain
Blood
Near infrared spectroscopy
Magnetic Resonance Spectroscopy
Near-Infrared Spectroscopy
Ischemia
Oxygenation
Experiments
Hypoxia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hapuarachchi, T., Moroz, T., Bainbridge, A., Price, D., Cady, E., Baer, E., ... Tachtsidis, I. (2013). Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes. In Advances in Experimental Medicine and Biology (Vol. 789, pp. 331-334). (Advances in Experimental Medicine and Biology; Vol. 789). Springer New York LLC. https://doi.org/10.1007/978-1-4614-7411-1_44

Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia : Simulating pH changes. / Hapuarachchi, Tharindi; Moroz, Tracy; Bainbridge, Alan; Price, David; Cady, Ernest; Baer, Esther; Broad, Kevin; Ezzati, Mojgan; Thomas, David; Golay, Xavier; Robertson, Nicola J.; Tachtsidis, Ilias.

Advances in Experimental Medicine and Biology. Vol. 789 Springer New York LLC, 2013. p. 331-334 (Advances in Experimental Medicine and Biology; Vol. 789).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hapuarachchi, T, Moroz, T, Bainbridge, A, Price, D, Cady, E, Baer, E, Broad, K, Ezzati, M, Thomas, D, Golay, X, Robertson, NJ & Tachtsidis, I 2013, Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes. in Advances in Experimental Medicine and Biology. vol. 789, Advances in Experimental Medicine and Biology, vol. 789, Springer New York LLC, pp. 331-334. https://doi.org/10.1007/978-1-4614-7411-1_44
Hapuarachchi T, Moroz T, Bainbridge A, Price D, Cady E, Baer E et al. Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes. In Advances in Experimental Medicine and Biology. Vol. 789. Springer New York LLC. 2013. p. 331-334. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-7411-1_44
Hapuarachchi, Tharindi ; Moroz, Tracy ; Bainbridge, Alan ; Price, David ; Cady, Ernest ; Baer, Esther ; Broad, Kevin ; Ezzati, Mojgan ; Thomas, David ; Golay, Xavier ; Robertson, Nicola J. ; Tachtsidis, Ilias. / Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia : Simulating pH changes. Advances in Experimental Medicine and Biology. Vol. 789 Springer New York LLC, 2013. pp. 331-334 (Advances in Experimental Medicine and Biology).
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