Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes

Tharindi Hapuarachchi; Tracy Moroz; Alan Bainbridge; David Price; Ernest Cady; Esther Baer; Kevin Broad; Mojgan Ezzati; David Thomas; Xavier Golay; Nicola J. Robertson; Ilias Tachtsidis

doi:10.1007/978-1-4614-7411-1_44

Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes

Tharindi Hapuarachchi, Tracy Moroz, Alan Bainbridge, David Price, Ernest Cady, Esther Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J. Robertson, Ilias Tachtsidis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using ³¹P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

Original language	English (US)
Title of host publication	Oxygen Transport to Tissue XXXV
Publisher	Springer New York LLC
Pages	331-334
Number of pages	4
ISBN (Print)	9781461472568
DOIs	https://doi.org/10.1007/978-1-4614-7411-1_44
State	Published - 2013
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	789
ISSN (Print)	0065-2598

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4614-7411-1_44

Cite this

Hapuarachchi, T., Moroz, T., Bainbridge, A., Price, D., Cady, E., Baer, E., Broad, K., Ezzati, M., Thomas, D., Golay, X., Robertson, N. J., & Tachtsidis, I. (2013). Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes. In Oxygen Transport to Tissue XXXV (pp. 331-334). (Advances in Experimental Medicine and Biology; Vol. 789). Springer New York LLC. https://doi.org/10.1007/978-1-4614-7411-1_44

Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia : Simulating pH changes. / Hapuarachchi, Tharindi; Moroz, Tracy; Bainbridge, Alan et al.

Oxygen Transport to Tissue XXXV. Springer New York LLC, 2013. p. 331-334 (Advances in Experimental Medicine and Biology; Vol. 789).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hapuarachchi, T, Moroz, T, Bainbridge, A, Price, D, Cady, E, Baer, E, Broad, K, Ezzati, M, Thomas, D, Golay, X, Robertson, NJ & Tachtsidis, I 2013, Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes. in Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology, vol. 789, Springer New York LLC, pp. 331-334. https://doi.org/10.1007/978-1-4614-7411-1_44

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abstract = "We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.",

author = "Tharindi Hapuarachchi and Tracy Moroz and Alan Bainbridge and David Price and Ernest Cady and Esther Baer and Kevin Broad and Mojgan Ezzati and David Thomas and Xavier Golay and Robertson, {Nicola J.} and Ilias Tachtsidis",

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AU - Hapuarachchi, Tharindi

AU - Moroz, Tracy

AU - Bainbridge, Alan

AU - Price, David

AU - Cady, Ernest

AU - Baer, Esther

AU - Broad, Kevin

AU - Ezzati, Mojgan

AU - Thomas, David

AU - Golay, Xavier

AU - Robertson, Nicola J.

AU - Tachtsidis, Ilias

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N2 - We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

AB - We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

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Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes

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