Modeling the scatter response function in inhomogeneous scattering media for SPECT

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We have previously developed a method for accurately and rapidly modeling the scatter response function in uniform media. In this work we studied the extension of this method to nonuniform attenuators. Our approach was to use the water-equivalent source depth, i.e. the integral of the attenuation coefficient through the nonuniform object from the source to the surface divided by the attenuation coefficient of water. We have investigated the accuracy of this approximation using Monte Carlo simulation methods. Line sources were placed at the same water equivalent depth in slabs composed of water, bone, and lung. We observed that, for perfect collimation, the scatter response functions (SRFs) obtained for these slabs are comparable at depths less than 10 cm. For larger source depths, the SRFs from the water and bone phantoms are equivalent, while the SRFs from lung phantoms are somewhat narrower. To separate the effects of the density and elemental composition, we simulated SRFs for bone- and lung-equivalent materials having the same elemental composition as water, but densities that result in the same attenuation coefficients as bone and lung, respectively. For the lung-equivalent material, the SRFs were essentially equivalent to those from lung; for the bone-equivalent material, the SRFs were closer to those from water. We have also placed voids of various sizes in slab phantoms while keeping the same water-equivalent source depth. For these simple geometries the effective depth was adequate for predicting the SRF. Finally, we have simulated the SRF for a line source in a realistic thorax phantom using several methods based on water-equivalent distances. The results indicate that one of the methods gives fair agreement with direct MC simulations in terms of predicting the magnitude and shape of the SRF.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium & Medical Imaging Conference
PublisherPubl by IEEE
Number of pages5
Editionpt 2
ISBN (Print)0780314875
StatePublished - 1994
Externally publishedYes
EventProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference - San Francisco, CA, USA
Duration: Oct 30 1993Nov 6 1993

Publication series

NameIEEE Nuclear Science Symposium & Medical Imaging Conference
Numberpt 2


OtherProceedings of the 1993 IEEE Nuclear Science Symposium & Medical Imaging Conference
CitySan Francisco, CA, USA

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Modeling the scatter response function in inhomogeneous scattering media for SPECT'. Together they form a unique fingerprint.

Cite this