Modeling the retinal horizontal cell layer on a massively parallel processor: A detailed neural network model

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the use of a massively parallel processor , the Connection Machine model CM-2, to simulate light responses of the horizontal cell network of the vertebrate outer retina. The network model is biophysically detailed; properties of all non-linear voltage-gated membrane currents and intracellular calcium buffering mechanisms are modeled. Implementation and efficiency of execution on CM-2 and Cray supercomputers is discussed. Computational properties of the horizontal cell network under light and dark adapted conditions are analyzed. Results demonstrate that an increase in cell coupling following light adaptation improves the temporal resolution of the network at the expense of decreased spatial resolution. These changes may perform matched filtering, adjusting the response kinetics of the horizontal cell network to match those of cone photoreceptors over a range of background light levels.

Original languageEnglish (US)
Title of host publicationProceedings of the 2nd IEEE Symposium on Parallel and Distributed Processing 1990, SPDP 1990
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages792-798
Number of pages7
ISBN (Electronic)0818620870, 9780818620874
DOIs
Publication statusPublished - Jan 1 1990
Externally publishedYes
Event2nd IEEE Symposium on Parallel and Distributed Processing, SPDP 1990 - Dallas, United States
Duration: Dec 9 1990Dec 13 1990

Publication series

NameProceedings of the 2nd IEEE Symposium on Parallel and Distributed Processing 1990, SPDP 1990

Conference

Conference2nd IEEE Symposium on Parallel and Distributed Processing, SPDP 1990
CountryUnited States
CityDallas
Period12/9/9012/13/90

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Hardware and Architecture

Cite this

Kimball, A. L., & Winslow, R. L. (1990). Modeling the retinal horizontal cell layer on a massively parallel processor: A detailed neural network model. In Proceedings of the 2nd IEEE Symposium on Parallel and Distributed Processing 1990, SPDP 1990 (pp. 792-798). [143647] (Proceedings of the 2nd IEEE Symposium on Parallel and Distributed Processing 1990, SPDP 1990). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SPDP.1990.143647