Modeling the impact of COPD on the brain

Soo Borson, James Scanlan, Seth Friedman, Elizabeth Zuhr, Julie Fields, Elizabeth H. Aylward, Rodney Mahurin, Todd Richards, Yoshimi Anzai, Michi Yukawa, Shingshing Yeh

Research output: Contribution to journalArticle

Abstract

Previous studies have shown that COPD adversely affects distant organs and body systems, including the brain. This pilot study aims to model the relationships between respiratory insufficiency and domains related to brain function, including low mood, subtly impaired cognition, systemic inflammation, and brain structural and neurochemical abnormalities. Nine healthy controls were compared with 18 age- and education-matched medically stable COPD patients, half of whom were oxygen-dependent. Measures included depression, anxiety, cognition, health status, spirometry, oximetry at rest and during 6-minute walk, and resting plasma cytokines and soluble receptors, brain MRI, and MR spectroscopy in regions relevant to mood and cognition. ANOVA was used to compare controls with patients and with COPD subgroups (oxygen users [n = 9] and nonusers [n = 9]), and only variables showing group differences at p ≤ 0.05 were included in multiple regressions controlling for age, gender, and education to develop the final model. Controls and COPD patients differed significantly in global cognition and memory, mood, and soluble TNFR1 levels but not brain structural or neurochemical measures. Multiple regressions identified pathways linking disease severity with impaired performance on sensitive cognitive processing measures, mediated through oxygen dependence, and with systemic inflammation (TNFR1), related through poor 6-minute walk performance. Oxygen desaturation with activity was related to indicators of brain tissue damage (increased frontal choline, which in turn was associated with subcortical white matter attenuation). This empirically derived model provides a conceptual framework for future studies of clinical interventions to protect the brain in patients with COPD, such as earlier oxygen supplementation for patients with desaturation during everyday activities.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalInternational Journal of COPD
Volume3
Issue number3
StatePublished - 2008
Externally publishedYes

Fingerprint

Chronic Obstructive Pulmonary Disease
Cognition
Oxygen
Brain
Receptors, Tumor Necrosis Factor, Type I
Education
Cytokine Receptors
Oximetry
Spirometry
Encephalitis
Choline
Respiratory Insufficiency
Health Status
Analysis of Variance
Magnetic Resonance Spectroscopy
Anxiety
Depression
Inflammation

Keywords

  • Cognition
  • Cytokines
  • Frontal choline
  • Mood
  • Oxygen desaturation
  • SGRQ

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Health Policy

Cite this

Borson, S., Scanlan, J., Friedman, S., Zuhr, E., Fields, J., Aylward, E. H., ... Yeh, S. (2008). Modeling the impact of COPD on the brain. International Journal of COPD, 3(3), 429-434.

Modeling the impact of COPD on the brain. / Borson, Soo; Scanlan, James; Friedman, Seth; Zuhr, Elizabeth; Fields, Julie; Aylward, Elizabeth H.; Mahurin, Rodney; Richards, Todd; Anzai, Yoshimi; Yukawa, Michi; Yeh, Shingshing.

In: International Journal of COPD, Vol. 3, No. 3, 2008, p. 429-434.

Research output: Contribution to journalArticle

Borson, S, Scanlan, J, Friedman, S, Zuhr, E, Fields, J, Aylward, EH, Mahurin, R, Richards, T, Anzai, Y, Yukawa, M & Yeh, S 2008, 'Modeling the impact of COPD on the brain', International Journal of COPD, vol. 3, no. 3, pp. 429-434.
Borson S, Scanlan J, Friedman S, Zuhr E, Fields J, Aylward EH et al. Modeling the impact of COPD on the brain. International Journal of COPD. 2008;3(3):429-434.
Borson, Soo ; Scanlan, James ; Friedman, Seth ; Zuhr, Elizabeth ; Fields, Julie ; Aylward, Elizabeth H. ; Mahurin, Rodney ; Richards, Todd ; Anzai, Yoshimi ; Yukawa, Michi ; Yeh, Shingshing. / Modeling the impact of COPD on the brain. In: International Journal of COPD. 2008 ; Vol. 3, No. 3. pp. 429-434.
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