Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls

Xueqi Chen, Manish Paranjpe, Rongfu Wang, David Dagan Feng, Yun Zhou, the Alzheimer's Disease Neuroimaging Initiative for the Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

Abstract

Apolipoprotein E (APOE) ε4 allele is a risk factor for developing Alzheimer's disease. In this study, we analyzed longitudinal changes in fluorodeoxyglucose (FDG) uptake between APOE ε4 carriers and non-carriers in normal control (NC) and Mild Cognitive Impairment (MCI) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We reported forebrain and limbic regions that exhibit APOE ε4-mediated declines in FDG uptake over a 96 month period in subjects with MCI but not NCs. Using voxel-based and ROI-based analysis, we compared the longitudinal changes in glucose uptake between APOE ε4 carriers and non-carriers from 34 NCs with no cognitive impairment and 48 subjects with MCI. Parietal, temporal and frontal regions had greater longitudinal decreases in FDG uptake in APOE ε4 carriers compared to non-carriers. The Superior parietal lobe, inferior temporal gyrus, thalamus, caudate, parahippocampal gyrus, fusiform gyrus and middle temporal gyrus showed greater longitudinal decreases in FDG uptake in APOE ε4 carriers compared to non-carriers in subjects with MCI but not NC. These findings suggest APOE ε4 genotype is associated with decline in glucose uptake over time and that specific limbic and forebrain structures exhibit APOE ε4-mediated FDG decline in MCI but not NCs. Our work in identifying the brain regions most associated with APOE ε4 related AD pathophysiology will improve quantitative FDG imaging as a biomarker in precision medicine.

Original languageEnglish (US)
Pages (from-to)396-401
Number of pages6
JournalIFAC-PapersOnLine
Volume51
Issue number27
DOIs
StatePublished - Jan 1 2018

Fingerprint

Glucose
Neuroimaging
Apolipoproteins
Biomarkers
Medicine
Brain
Imaging techniques

Keywords

  • Alzheimer's Disease
  • APOE ε4
  • FDG
  • Functional neuroimaging

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Chen, X., Paranjpe, M., Wang, R., Feng, D. D., Zhou, Y., & for the Alzheimer's Disease Neuroimaging Initiative, T. A. D. N. I. (2018). Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls. IFAC-PapersOnLine, 51(27), 396-401. https://doi.org/10.1016/j.ifacol.2019.02.002

Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls. / Chen, Xueqi; Paranjpe, Manish; Wang, Rongfu; Feng, David Dagan; Zhou, Yun; for the Alzheimer's Disease Neuroimaging Initiative, the Alzheimer's Disease Neuroimaging Initiative.

In: IFAC-PapersOnLine, Vol. 51, No. 27, 01.01.2018, p. 396-401.

Research output: Contribution to journalArticle

Chen, X, Paranjpe, M, Wang, R, Feng, DD, Zhou, Y & for the Alzheimer's Disease Neuroimaging Initiative, TADNI 2018, 'Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls', IFAC-PapersOnLine, vol. 51, no. 27, pp. 396-401. https://doi.org/10.1016/j.ifacol.2019.02.002
Chen X, Paranjpe M, Wang R, Feng DD, Zhou Y, for the Alzheimer's Disease Neuroimaging Initiative TADNI. Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls. IFAC-PapersOnLine. 2018 Jan 1;51(27):396-401. https://doi.org/10.1016/j.ifacol.2019.02.002
Chen, Xueqi ; Paranjpe, Manish ; Wang, Rongfu ; Feng, David Dagan ; Zhou, Yun ; for the Alzheimer's Disease Neuroimaging Initiative, the Alzheimer's Disease Neuroimaging Initiative. / Modeling Spatial and Temporal Patterns of APOE ε4 Mediated Glucose Uptake in Mild Cognitive Impairment and Normal Controls. In: IFAC-PapersOnLine. 2018 ; Vol. 51, No. 27. pp. 396-401.
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