Modeling Responses to Peripheral Nerve Stimulation in the Dorsal Horn

Christine Beauchene, Pierre Sacre, Fei Yang, Yun Guan, Sridevi V. Sarma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pain is a protective physiological system essential for survival. However, it can malfunction and create a debilitating disease known as chronic pain (CP). CP is primarily treated with drugs that can have negative side effects (e.g., opioid addiction), and lose efficacy after long-term use. Electrical stimulation of the spinal cord or peripheral nerves is an alternative therapy that has great potential to reduce the need for drugs and has fewer negative side effects; but has been associated with suboptimal efficacy because its modulation mechanisms are unknown. Critical to advancing CP treatment is a deeper understanding of how pain is processed in the superficial and deep layers of the dorsal horn (DH), which is the first central relay station for pain processing in the spinal cord. Mechanistic models of the DH have been developed to investigate modulation mechanisms but are non-linear and high-dimensional and thus difficult to analyze. In this paper, we construct a tractable computational model of the DH in rats from LFP recordings of the superficial layer network and spiking activity of WDR neurons in the deep layer. By combining a deterministic linear time-invariant model with a stochastic point process model, we can accurately predict responses of the DH circuit to electrical stimulation of the peripheral nerve. The model is computationally efficient, low-dimensional, and able to capture the stochastic nature of neuronal dynamics in the DH; and is a first step in developing new therapies for CP.

Original languageEnglish (US)
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2324-2327
Number of pages4
ISBN (Electronic)9781538613115
DOIs
StatePublished - Jul 2019
Event41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Germany
Duration: Jul 23 2019Jul 27 2019

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
CountryGermany
CityBerlin
Period7/23/197/27/19

Fingerprint

Peripheral Nerves
Chronic Pain
Pain
Electric Stimulation
Modulation
Stochastic Processes
Spinal Cord Stimulation
Spinal Nerves
Network layers
Complementary Therapies
Pharmaceutical Preparations
Opioid Analgesics
Neurons
Rats
Spinal Cord
Spinal Cord Dorsal Horn
Networks (circuits)
Therapeutics
Processing

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Beauchene, C., Sacre, P., Yang, F., Guan, Y., & Sarma, S. V. (2019). Modeling Responses to Peripheral Nerve Stimulation in the Dorsal Horn. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 2324-2327). [8856566] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8856566

Modeling Responses to Peripheral Nerve Stimulation in the Dorsal Horn. / Beauchene, Christine; Sacre, Pierre; Yang, Fei; Guan, Yun; Sarma, Sridevi V.

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 2324-2327 8856566 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Beauchene, C, Sacre, P, Yang, F, Guan, Y & Sarma, SV 2019, Modeling Responses to Peripheral Nerve Stimulation in the Dorsal Horn. in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8856566, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 2324-2327, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, Berlin, Germany, 7/23/19. https://doi.org/10.1109/EMBC.2019.8856566
Beauchene C, Sacre P, Yang F, Guan Y, Sarma SV. Modeling Responses to Peripheral Nerve Stimulation in the Dorsal Horn. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 2324-2327. 8856566. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2019.8856566
Beauchene, Christine ; Sacre, Pierre ; Yang, Fei ; Guan, Yun ; Sarma, Sridevi V. / Modeling Responses to Peripheral Nerve Stimulation in the Dorsal Horn. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 2324-2327 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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