Modeling psychiatric disorders with patient-derived iPSCs

Zhexing Wen, Kimberly M. Christian, Hongjun Song, Guo li Ming

Research output: Contribution to journalReview article

Abstract

Psychiatric disorders are heterogeneous disorders characterized by complex genetics, variable symptomatology, and anatomically distributed pathology, all of which present challenges for effective treatment. Current treatments are often blunt tools used to ameliorate the most severe symptoms, often at the risk of disrupting functional neural systems, thus there is a pressing need to develop rational therapeutics. Induced pluripotent stem cells (iPSCs) reprogrammed from patient somatic cells offer an unprecedented opportunity to recapitulate both normal and pathologic human tissue and organ development, and provides new approaches for understanding disease mechanisms and for drug discovery with higher predictability of their effects in humans. Here we review recent progress and challenges in using human iPSCs for modeling neuropsychiatric disorders and developing novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume36
DOIs
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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