Modeling neurological diseases using patient-derived induced pluripotent stem cells

Tarja A. Juopperi, Hongjun Song, Guo Li Ming

Research output: Contribution to journalArticle

Abstract

Reprogramming of somatic cells to an embryonic-like state has dramatically changed the landscape of stem cell research. Although still in its formative stages, the field of induced pluripotent stem cells (iPSCs) has the potential to advance the study of neurodegenerative and neurodevelopmental disorders at the molecular and cellular levels. The iPSC technology could be employed to establish in vitro experimental model systems for the identification of molecular lesions and to aid in the discovery of therapeutic targets and effective compounds. The derivation of patient-specific iPSCs has also opened up the possibility of generating disease-relevant cells for toxicity screening and for cellular therapy. In this article, we review the recent progress in the use of disease-specific iPSCs for in vitro and in vivo modeling of neurological diseases.

Original languageEnglish (US)
Pages (from-to)363-373
Number of pages11
JournalFuture Neurology
Volume6
Issue number3
DOIs
StatePublished - May 2011

Keywords

  • disease modeling
  • human induced pluripotent stem cell
  • neurobiology
  • neurodegenerative
  • neurodevelopmental

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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