TY - JOUR
T1 - Modeling neurodevelopmental and psychiatric diseases with human iPSCs
AU - Wen, Zhexing
N1 - Funding Information:
I thank Drs. Hongjun Song and Guo-li Ming at Johns Hopkins University School of Medicine for their support. The research in the author's laboratory was supported by a start-up fund from Emory University.
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Neurodevelopmental and psychiatric disorders, including autism spectrum disorder and schizophrenia, are complex and heterogeneous disorders that affect a large portion of the world's population. While the causes are still poorly understood, currently available treatments are limited; the development of rational therapeutics based on an understanding of the etiology and pathogenesis of the disease is imperative. The breakthrough technology of deriving induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of healthy subjects or patients, offers an unprecedented opportunity to recapitulate both normal and pathological development of human tissue, thereby opening up a new avenue for disease modeling and drug development in a more genetically tractable and disease-relevant system. Here, I review the recent progress in the use of human iPSCs for modeling neurodevelopmental and psychiatric disorders and developing novel therapeutic strategies, and discuss challenges in this rapidly moving field.
AB - Neurodevelopmental and psychiatric disorders, including autism spectrum disorder and schizophrenia, are complex and heterogeneous disorders that affect a large portion of the world's population. While the causes are still poorly understood, currently available treatments are limited; the development of rational therapeutics based on an understanding of the etiology and pathogenesis of the disease is imperative. The breakthrough technology of deriving induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of healthy subjects or patients, offers an unprecedented opportunity to recapitulate both normal and pathological development of human tissue, thereby opening up a new avenue for disease modeling and drug development in a more genetically tractable and disease-relevant system. Here, I review the recent progress in the use of human iPSCs for modeling neurodevelopmental and psychiatric disorders and developing novel therapeutic strategies, and discuss challenges in this rapidly moving field.
KW - disease modeling
KW - drug discovery
KW - human-induced pluripotent stem cells
KW - neurodevelopmental disorders
KW - psychiatric disorders
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U2 - 10.1002/jnr.24031
DO - 10.1002/jnr.24031
M3 - Review article
C2 - 28186671
AN - SCOPUS:85012993321
SN - 0360-4012
VL - 95
SP - 1097
EP - 1109
JO - Journal of neuroscience research
JF - Journal of neuroscience research
IS - 5
ER -