Modeling Intercellular Transfer of Biomolecules Through Tunneling Nanotubes

Yasir Suhail, Kshitiz, Justin Lee, Mark Walker, Deok Ho Kim, Matthew D. Brennan, Joel S. Bader, Andre Levchenko

Research output: Contribution to journalArticlepeer-review

Abstract

Tunneling nanotubes (TNTs) have previosly been observed as long and thin transient structures forming between cells and intercellular protein transfer through them has been experimentally verified. It is hypothesized that this may be a physiologically important means of cell-cell communication. This paper attempts to give a simple model for the rates of transfer of molecules across these TNTs at different distances. We describe the transfer of both cytosolic and membrane bound molecules between neighboring populations of cells and argue how the lifetime of the TNT, the diffusion rate, distance between cells, and the size of the molecules may affect their transfer. The model described makes certain predictions and opens a number of questions to be explored experimentally.

Original languageEnglish (US)
Pages (from-to)1400-1416
Number of pages17
JournalBulletin of Mathematical Biology
Volume75
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

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