Modeling in vivo pharmacokinetics and pharmacodynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system

Amy Sarah Ginsburg, Jin Lee, Samuel C. Woolwine, Jacques H. Grosset, Fayez M. Hamzeh, William R. Bishai

Research output: Contribution to journalArticle

Abstract

To study the efficacy of moxifloxacin treatment for tuberculosis, we utilized a novel cartridge system to simulate in vivo pharmacokinetics. We found this system to be a robust method for modeling in vivo pharmacokinetics and present data supporting the utility of intermittent moxifloxacin treatment as a component of antituberculosis chemotherapy.

Original languageEnglish (US)
Pages (from-to)853-856
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number2
DOIs
StatePublished - Feb 1 2005

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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