Modeling HIV persistence and cure studies

Research output: Contribution to journalReview articlepeer-review


PURPOSE OF REVIEW: To provide a summary of the contributions of mathematical modeling to understanding of HIV persistence during antiretroviral therapy. RECENT FINDINGS: Although HIV persistence during therapy could be caused by continual viral replication or slow-decaying latent infection, most evidence points toward the latter mechanism. The latent reservoir is maintained by a balance of cell death, proliferation, and reactivation, and new methods to estimate the relative contributions of these rates use a wide range of experimental data. This has led to new quantitative predictions about the potential benefit of therapies such as latency-reversing agents or antiproliferative drugs. SUMMARY: Results of these mathematical modeling studies can be used to design and interpret future trials of new therapies targeting HIV persistence.

Original languageEnglish (US)
Pages (from-to)428-434
Number of pages7
JournalCurrent opinion in HIV and AIDS
Issue number5
StatePublished - Sep 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Hematology
  • Oncology
  • Oncology(nursing)
  • Infectious Diseases
  • Virology


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