Modeling glioma growth and mass effect in 3D MR images of the brain.

Cosmina Hogea, Christos Davatzikos, George Biros

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this article, we propose a framework for modeling glioma growth and the subsequent mechanical impact on the surrounding brain tissue (mass-effect) in a medical imaging context. Glioma growth is modeled via nonlinear reaction-advection-diffusion, with a two-way coupling with the underlying tissue elastic deformation. Tumor bulk and infiltration and subsequent mass-effects are not regarded separately, but captured by the model itself in the course of its evolution. Our formulation is fully Eulerian and naturally allows for updating the tumor diffusion coefficient following structural displacements caused by tumor growth/infiltration. We show that model parameters can be estimated via optimization based on imaging data, using efficient solution algorithms on regular grids. We test the model and the automatic optimization framework on real brain tumor data sets, achieving significant improvement in landmark prediction compared to a simplified purely mechanical approach.

Original languageEnglish (US)
Title of host publicationMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
Pages642-650
Number of pages9
Volume10
EditionPt 1
StatePublished - 2007
Externally publishedYes

Fingerprint

Glioma
Brain
Growth
Neoplasms
Elastic Tissue
Diagnostic Imaging
Brain Neoplasms
Datasets

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hogea, C., Davatzikos, C., & Biros, G. (2007). Modeling glioma growth and mass effect in 3D MR images of the brain. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention (Pt 1 ed., Vol. 10, pp. 642-650)

Modeling glioma growth and mass effect in 3D MR images of the brain. / Hogea, Cosmina; Davatzikos, Christos; Biros, George.

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 10 Pt 1. ed. 2007. p. 642-650.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hogea, C, Davatzikos, C & Biros, G 2007, Modeling glioma growth and mass effect in 3D MR images of the brain. in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 1 edn, vol. 10, pp. 642-650.
Hogea C, Davatzikos C, Biros G. Modeling glioma growth and mass effect in 3D MR images of the brain. In Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Pt 1 ed. Vol. 10. 2007. p. 642-650
Hogea, Cosmina ; Davatzikos, Christos ; Biros, George. / Modeling glioma growth and mass effect in 3D MR images of the brain. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. Vol. 10 Pt 1. ed. 2007. pp. 642-650
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