Modeling depression in Parkinson disease: Disease-specific and nonspecific risk factors

Albert F G Leentjens, Anja J H Moonen, Kathy Dujardin, Laura Marsh, Pablo Martinez-Martin, Irene H. Richard, Sergio E. Starkstein, Sebastian Köhler

Research output: Contribution to journalArticle

Abstract

Objective: To construct a model for depression in Parkinson disease (PD) and to study the relative contribution of PD-specific and nonspecific risk factors to this model. Methods: Structural equation modeling of direct and indirect associations of risk factors with the latent depression outcome using a cross-sectional dataset of 342 patients with PD. Results: Amodel with acceptable fitwas generated that explained 41% of the variance in depression. In the final model, 3 PD-specific variables (increased disease duration, more severe motor symptoms, the use of levodopa) and 6 nonspecific variables (female sex, history of anxiety and/or depression, family history of depression, worse functioning on activities of daily living, and worse cognitive status) were maintained and significantly associated with depression. Nonspecific risk factors had a 3-timeshigher influence in the model than PD-specific risk factors. Conclusion: In this cross-sectional study, we showed that nonspecific factors may be more prominent markers of depression than PD-specific factors. Accordingly, research on depression in PD should focus not only on factors associated with or specific for PD, but should also examine a wider scope of factors including general risk factors for depression, not specific for PD.

Original languageEnglish (US)
Pages (from-to)1036-1043
Number of pages8
JournalNeurology
Volume81
Issue number12
DOIs
StatePublished - Sep 17 2013
Externally publishedYes

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Parkinson Disease
Depression
Modeling
Parkinson's Disease
Risk Factors
Levodopa
Activities of Daily Living
Anxiety
Cross-Sectional Studies
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Leentjens, A. F. G., Moonen, A. J. H., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I. H., ... Köhler, S. (2013). Modeling depression in Parkinson disease: Disease-specific and nonspecific risk factors. Neurology, 81(12), 1036-1043. https://doi.org/10.1212/WNL.0b013e3182a4a503

Modeling depression in Parkinson disease : Disease-specific and nonspecific risk factors. / Leentjens, Albert F G; Moonen, Anja J H; Dujardin, Kathy; Marsh, Laura; Martinez-Martin, Pablo; Richard, Irene H.; Starkstein, Sergio E.; Köhler, Sebastian.

In: Neurology, Vol. 81, No. 12, 17.09.2013, p. 1036-1043.

Research output: Contribution to journalArticle

Leentjens, AFG, Moonen, AJH, Dujardin, K, Marsh, L, Martinez-Martin, P, Richard, IH, Starkstein, SE & Köhler, S 2013, 'Modeling depression in Parkinson disease: Disease-specific and nonspecific risk factors', Neurology, vol. 81, no. 12, pp. 1036-1043. https://doi.org/10.1212/WNL.0b013e3182a4a503
Leentjens AFG, Moonen AJH, Dujardin K, Marsh L, Martinez-Martin P, Richard IH et al. Modeling depression in Parkinson disease: Disease-specific and nonspecific risk factors. Neurology. 2013 Sep 17;81(12):1036-1043. https://doi.org/10.1212/WNL.0b013e3182a4a503
Leentjens, Albert F G ; Moonen, Anja J H ; Dujardin, Kathy ; Marsh, Laura ; Martinez-Martin, Pablo ; Richard, Irene H. ; Starkstein, Sergio E. ; Köhler, Sebastian. / Modeling depression in Parkinson disease : Disease-specific and nonspecific risk factors. In: Neurology. 2013 ; Vol. 81, No. 12. pp. 1036-1043.
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