Modeling cardiac ion channel conductivity: Model fitting via simulation

John L. Maryak, Richard H. Smith, Raimond Winslow

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a Markov state model for a cloned potassium channel of the human heart (IKvLQT1). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the `SPSA' optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the action of the channel at that trial parameter value. When the optimizer has converged, the parameter value represents the best fit.

Original languageEnglish (US)
Title of host publicationWinter Simulation Conference Proceedings
PublisherIEEE
Pages1587-1590
Number of pages4
Volume2
StatePublished - 1998
EventProceedings of the 1998 Winter Simulation Conference, WSC. Part 1 (of 2) - Washington, DC, USA
Duration: Dec 13 1998Dec 16 1998

Other

OtherProceedings of the 1998 Winter Simulation Conference, WSC. Part 1 (of 2)
CityWashington, DC, USA
Period12/13/9812/16/98

Fingerprint

Ion Channels
Model Fitting
Cardiac
Conductivity
Potassium Channels
Ions
Modeling
Potassium
Simulation
Loss Function
Least Squares
Choose
Model

ASJC Scopus subject areas

  • Chemical Health and Safety
  • Software
  • Safety, Risk, Reliability and Quality
  • Applied Mathematics
  • Modeling and Simulation

Cite this

Maryak, J. L., Smith, R. H., & Winslow, R. (1998). Modeling cardiac ion channel conductivity: Model fitting via simulation. In Winter Simulation Conference Proceedings (Vol. 2, pp. 1587-1590). IEEE.

Modeling cardiac ion channel conductivity : Model fitting via simulation. / Maryak, John L.; Smith, Richard H.; Winslow, Raimond.

Winter Simulation Conference Proceedings. Vol. 2 IEEE, 1998. p. 1587-1590.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Maryak, JL, Smith, RH & Winslow, R 1998, Modeling cardiac ion channel conductivity: Model fitting via simulation. in Winter Simulation Conference Proceedings. vol. 2, IEEE, pp. 1587-1590, Proceedings of the 1998 Winter Simulation Conference, WSC. Part 1 (of 2), Washington, DC, USA, 12/13/98.
Maryak JL, Smith RH, Winslow R. Modeling cardiac ion channel conductivity: Model fitting via simulation. In Winter Simulation Conference Proceedings. Vol. 2. IEEE. 1998. p. 1587-1590
Maryak, John L. ; Smith, Richard H. ; Winslow, Raimond. / Modeling cardiac ion channel conductivity : Model fitting via simulation. Winter Simulation Conference Proceedings. Vol. 2 IEEE, 1998. pp. 1587-1590
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